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Plasma Tenascin-C: a prognostic biomarker in heart failure with preserved ejection fraction.
Kanagala, Prathap; Arnold, Jayanth R; Khan, Jamal N; Singh, Anvesha; Gulsin, Gaurav S; Chan, Daniel C S; Cheng, Adrian S H; Yang, Jing; Li, Zhuyin; Gupta, Pankaj; Squire, Iain B; McCann, Gerry P; Ng, Leong L.
Afiliación
  • Kanagala P; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Arnold JR; Department of Cardiology, Aintree University Hospital, Liverpool, UK.
  • Khan JN; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Singh A; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Gulsin GS; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Chan DCS; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Cheng ASH; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Yang J; Kettering General Hospital NHS Foundation Trust, UK.
  • Li Z; Bristol-Myers Squibb, Princeton, NJ, USA.
  • Gupta P; Bristol-Myers Squibb, Princeton, NJ, USA.
  • Squire IB; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • McCann GP; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
  • Ng LL; Department of Cardiovascular Sciences and the National Institute for Health Research (NIHR) Leicester, Biomedical Research Centre, Leicester, UK.
Biomarkers ; 25(7): 556-565, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32803990
INTRODUCTION: Tenascin-C is a marker of interstitial fibrosis. We assessed whether plasma Tenascin-C differed between heart failure with preserved ejection fraction (HFpEF) and asymptomatic controls and related to clinical outcomes. MATERIALS AND METHODS: Prospective, observational study of 172 age- and sex-matched subjects (HFpEF n = 130; controls n = 42, age 73 ± 9, males 50%) who underwent phenotyping with 20 plasma biomarkers, echocardiography, cardiac MRI and 6-minute-walk-testing. The primary endpoint was the composite of all-cause death/HF hospitalisation. RESULTS: Tenascin-C was higher in HFpEF compared to controls (13.7 [10.8-17.3] vs (11.1 [8.9-12.9] ng/ml, p < 0.0001). Tenascin-C correlated positively with markers of clinical severity (NYHA, E/E', BNP) and plasma biomarkers reflecting interstitial fibrosis (ST-2, Galectin-3, GDF-15, TIMP-1, TIMP-4, MMP-2, MMP-3, MMP-7, MMP-8), cardiomyocyte stress (BNP, NTpro-ANP), inflammation (MPO, hs-CRP, TNFR-1, IL6) and renal dysfunction (urea, cystatin-C, NGAL); p < 0.05 for all. During follow-up (median 1428 days), there were 61 composite events (21 deaths, 40 HF hospitalizations). In multivariable Cox regression analysis, Tenascin-C (adjusted hazard ratio [HR] 1.755, 95% confidence interval [CI] 1.305-2.360; p < 0.0001) and indexed extracellular volume (HR 1.465, CI 1.019-2.106; p = 0.039) were independently associated with adverse outcomes. CONCLUSIONS: In HFpEF, plasma Tenascin-C is higher compared to age- and sex-matched controls and a strong predictor of adverse outcomes. Trial registration: ClinicalTrials.gov: NCT03050593.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pronóstico / Biomarcadores / Tenascina / Insuficiencia Cardíaca Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pronóstico / Biomarcadores / Tenascina / Insuficiencia Cardíaca Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido