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Effect of aqueous extracts of Ficus vogeliana Miq and Tieghemella africana Pierre in 7,12-Dimethylbenz(a)anthracene -induced skin cancer in rats.
Ngoua Meye Misso, Rick-Léonid; Nsole Biteghe, Fleury Augustin; Obiang, Cédric Sima; Ondo, Joseph-Privat; Gao, Nan; Cervantes-Cervantes, Miguel; Vignaux, Guillaume; Vergeade, Aurelia; Engohang-Ndong, Jean; Mendene, Hugue Ella; Mabika, Barthelemy; Abessolo, Félix Ovono; Obame Engonga, Louis-Clement; De La Croix Ndong, Jean.
Afiliación
  • Ngoua Meye Misso RL; Universite des Sciences et Techniques de Masuku (USTM), Department of Chemistry, Franceville, Gabon. Electronic address: ngouamartel@gmail.com.
  • Nsole Biteghe FA; Department of Radiation Oncology and Biomedical Sciences, Cedars-Sinai Medical, 8700, Beverly Blvd, Los Angeles, USA.
  • Obiang CS; Universite des Sciences et Techniques de Masuku (USTM), Department of Chemistry, Franceville, Gabon.
  • Ondo JP; Universite des Sciences et Techniques de Masuku (USTM), Department of Chemistry, Franceville, Gabon.
  • Gao N; Rutgers University School of Arts & Sciences, Federated Departments of Biological Sciences, Newark, NJ, USA.
  • Cervantes-Cervantes M; Rutgers University School of Arts & Sciences, Federated Departments of Biological Sciences, Newark, NJ, USA.
  • Vignaux G; Arctic Slope Regional Corporation Federal, Arlington, VA, USA.
  • Vergeade A; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Engohang-Ndong J; Kent State University at Tuscarawas, New Philadelphia, OH, USA.
  • Mendene HE; Université des Sciences de La Santé, Département de Chimie et Biochimie, Libreville, Gabon.
  • Mabika B; Université des Sciences de La Santé, Département D'Anatomie Pathologie, Libreville, Gabon.
  • Abessolo FO; Université des Sciences de La Santé, Département de Chimie et Biochimie, Libreville, Gabon.
  • Obame Engonga LC; Universite des Sciences et Techniques de Masuku (USTM), Department of Chemistry, Franceville, Gabon.
  • De La Croix Ndong J; Arctic Slope Regional Corporation Federal, Arlington, VA, USA; New York University, School of Medicine, Department of Orthopedic Surgery, New York, USA.
J Ethnopharmacol ; 263: 113244, 2020 Dec 05.
Article en En | MEDLINE | ID: mdl-32800931
ETHNOPHARMACOLOGICAL RELEVANCE: Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality. Tieghemella africana and Ficus vogeliana are used in traditional medicine to treat cancers. AIM OF THE STUDY: Therefore, the aim of this study was to investigate the antioxidant, antiangiogenic and anti-tumor activities of these plant extracts. MATERIALS AND METHODS: To achieve it, phytochemical screening, antioxidant activity and antiangiogenic activity were assessed. Thereafter, the anti-tumor activity was determined using skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene. RESULTS: The phytochemical result analysis showed that both plant extracts were rich in polyphenols, alkaloids and terpene compounds and possessed good antioxidant activity based on DPPH radical scavenging (IC50 = 9.70 µg/mL and 4.60 µg/mL and AAI values of 5.20 and 10.88) and strong total antioxidant capacity (115.44 VtCE (mg)/g of dry plant extract and 87.37 VtCE (mg)/g of dry plant extract, respectively). Additionally, both plant extracts possessed antiangiogenic activities (IC50 = 53.43 µg/mL and 92.68 µg/mL, respectively), which correlated with significant antitumor activities when using 35 mg/kg (65.02% and 77.54%) and 70 mg/kg of extracts (81.07% and 88.18%). CONCLUSIONS: In summary, this study illustrates the promising usage of Tieghemella africana and Ficus vogeliana plant extracts in treating skin cancer. However, further characterization of the extracts must be performed to isolate the most active anticancer compound.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Extractos Vegetales / Ficus / Sapotaceae / 9,10-Dimetil-1,2-benzantraceno Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Extractos Vegetales / Ficus / Sapotaceae / 9,10-Dimetil-1,2-benzantraceno Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda