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The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.
Shah, Vidhi P; Raffay, Thomas M; Martin, Richard J; Vento, Máximo; Sánchez-Illana, Ángel; Piñeiro-Ramos, José David; Kuligowski, Julia; Di Fiore, Juliann M.
Afiliación
  • Shah VP; Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
  • Raffay TM; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
  • Martin RJ; Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
  • Vento M; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
  • Sánchez-Illana Á; Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
  • Piñeiro-Ramos JD; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
  • Kuligowski J; Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain.
  • Di Fiore JM; Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain.
Neonatology ; 117(5): 577-583, 2020.
Article en En | MEDLINE | ID: mdl-32799210
INTRODUCTION: Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels of lipid peroxidation products and increased intermittent hypoxemia (IH) events have been associated with adverse outcomes in extremely preterm infants. The moderate preterm newborn has a still-developing oxidant defense system and immature respiratory control, but little is known about lipid peroxidation levels and IH in this larger and more common preterm population. OBJECTIVE: To determine the association between oxidative stress and IH in moderate preterm infants. METHOD: Oxygen saturation was continuously monitored in 51 moderate preterm infants (i.e., 31 + 0/7 to 33 + 6/7 weeks' gestation). Urine samples were collected at the end of the first and second weeks of life. Samples were analyzed for total lipid peroxidation products (neurofurans, isofurans, neuroprostanes, isoprostanes, and di-homo-isofurans). RESULT: At week 1, there was a correlation between increased IH frequency and neurofurans (p < 0.04) and di-homo-isofurans (p < 0.003). At week 2, there was no correlation between IH and lipid peroxidation markers. Ele-vations in neurofurans, isofurans, neuroprostanes, and di-homo-isofurans in the first and/or second week of life were associated with a longer stay in hospital. CONCLUSION: Elevations in lipid peroxidation biomarkers in moderate preterm infants during their first weeks of life are associated with a higher frequency of IH and prolonged hospitalization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Recien Nacido Extremadamente Prematuro / Hipoxia Límite: Humans / Infant / Newborn Idioma: En Revista: Neonatology Asunto de la revista: PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Recien Nacido Extremadamente Prematuro / Hipoxia Límite: Humans / Infant / Newborn Idioma: En Revista: Neonatology Asunto de la revista: PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza