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Tryptophan-kynurenine ratio as a biomarker of bladder cancer.
Lee, Sze Han; Mahendran, Ratha; Tham, Sin Mun; Thamboo, Thomas Paulraj; Chionh, Billy Jianhao; Lim, Yi Xin; Tsang, Woon Chau; Wu, Qing Hui; Chia, Jun Yang; Tay, Melissa Hui Wen; Goh, Benjamin Yen Seow; Chen, Kelven Weijing; Mallari, Jeane Zepeda; Periaswami, Revathi; Raman, Lata; Choo, Shoa Nian; Kioh, Dorinda Yan Qin; Chiong, Edmund; Esuvaranathan, Kesavan; Chan, Eric Chun Yong.
Afiliación
  • Lee SH; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Mahendran R; Department of Surgery, National University of Singapore, Singapore City, Singapore.
  • Tham SM; Department of Surgery, National University of Singapore, Singapore City, Singapore.
  • Thamboo TP; Department of Urology, National University Health System, Singapore City, Singapore.
  • Chionh BJ; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Lim YX; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Tsang WC; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Wu QH; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Chia JY; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Tay MHW; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Goh BYS; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Chen KW; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Mallari JZ; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Periaswami R; Department of Surgery, National University of Singapore, Singapore City, Singapore.
  • Raman L; Department of Surgery, National University of Singapore, Singapore City, Singapore.
  • Choo SN; Department of Urology, National University Health System, Singapore City, Singapore.
  • Kioh DYQ; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Chiong E; Department of Surgery, National University of Singapore, Singapore City, Singapore.
  • Esuvaranathan K; Department of Pathology, National University Health System, Singapore City, Singapore.
  • Chan ECY; Department of Surgery, National University of Singapore, Singapore City, Singapore.
BJU Int ; 127(4): 445-453, 2021 04.
Article en En | MEDLINE | ID: mdl-32794357
OBJECTIVES: To investigate plasma and urinary kynurenine (KYN)-tryptophan (TRP) ratios in bladder cancer, expression of indoleamine 2,3-dioxygenase 1 (IDO1) in relation to tryptophan 2,3-dioxygenase (TDO2) in bladder tumour, and the correlation of KYN-TRP ratio with bladder tumour burden. METHODS: Metabotyping of the TRP-KYN metabolic axis was performed via a clinical case-control study. Expression of IDO1 and TDO2 was measured in human biopsied tissues. Correlational experiments between KYN-TRP ratio and bladder tumour were performed using a murine orthotopic prostate-specific antigen (PSA)-secreting MB49 bladder cancer model. RESULTS: We established for the first time that plasma TRP level was significantly decreased, while both plasma and urinary KYN-TRP ratios were significantly higher in bladder cancer patients, and expression level of IDO1 but not TDO2 was increased in human bladder tumour. We reported the positive correlation between IDO1 expression, KYN-TRP ratio, normalized PSA to creatinine, and bladder tumour burden in the murine model. CONCLUSION: Kynurenine-tryptophan ratio is a promising surveillance biomarker for bladder cancer, but would require further validation before clinical translation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Neoplasias de la Vejiga Urinaria / Biomarcadores de Tumor / Quinurenina Tipo de estudio: Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Neoplasias de la Vejiga Urinaria / Biomarcadores de Tumor / Quinurenina Tipo de estudio: Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido