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Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and health economic analysis plan for the 65 trial in article.
Thomas, Karen; Patel, Akshay; Sadique, M Zia; Grieve, Richard D; Mason, Alexina J; Moler, Silvia; Gordon, Anthony C; Rowan, Kathryn M; Mouncey, Paul R; Lamontagne, Francois; Harrison, David A.
Afiliación
  • Thomas K; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • Patel A; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • Sadique MZ; Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.
  • Grieve RD; Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.
  • Mason AJ; Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.
  • Moler S; Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.
  • Gordon AC; Section of Anaesthetics, Pain Medicine & Intensive Care, Imperial College London, London, UK.
  • Rowan KM; Intensive Care Unit, Imperial College Healthcare NHS Trust, London, UK.
  • Mouncey PR; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • Lamontagne F; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • Harrison DA; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke et Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Canada.
J Intensive Care Soc ; 21(3): 230-231, 2020 Aug.
Article en En | MEDLINE | ID: mdl-32782462
The 65 trial is a pragmatic, multicentre, parallel-group, open-label, randomised clinical trial of permissive hypotension (targeting a mean arterial pressure target of 60-65 mmHg during vasopressor therapy) versus usual care in critically ill patients aged 65 years or over with vasodilatory hypotension. The trial will recruit 2600 patients from 65 United Kingdom adult general critical care units. The primary outcome is all-cause mortality at 90 days. An economic evaluation is embedded. This paper describes the proposed statistical and health economic analysis for the 65 trial.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Health_economic_evaluation Idioma: En Revista: J Intensive Care Soc Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Health_economic_evaluation Idioma: En Revista: J Intensive Care Soc Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido