Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers.

Esmaili, Mansoore; Brown, Chanelle J; Shaykhutdinov, Rustem; Acevedo-Morantes, Claudia; Wang, Yong Liang; Wille, Holger; Gandour, Richard D; Turner, S Richard; Overduin, Michael

Esmaili, Mansoore; Brown, Chanelle J; Shaykhutdinov, Rustem; Acevedo-Morantes, Claudia; Wang, Yong Liang; Wille, Holger; Gandour, Richard D; Turner, S Richard; Overduin, Michael.

Afiliación

Esmaili M; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Overduin@ualberta.ca.
Brown CJ; Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA. gandour@vt.edu.
Shaykhutdinov R; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Overduin@ualberta.ca.
Acevedo-Morantes C; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.
Wang YL; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.
Wille H; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada.
Gandour RD; Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA. gandour@vt.edu.
Turner SR; Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA. gandour@vt.edu.
Overduin M; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Overduin@ualberta.ca.

Nanoscale ; 12(32): 16705-16709, 2020 Aug 20.

Article en En | MEDLINE | ID: mdl-32780785

RESUMEN

Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with â¼20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanoscale Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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