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Effects of peri-implant infection on serum biochemical analysis.
Chaushu, Liat; Tal, Haim; Sculean, Anton; Fernández-Tomé, Blanca; Chaushu, Gavriel.
Afiliación
  • Chaushu L; Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Tal H; Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Sculean A; Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
  • Fernández-Tomé B; Laparoscopy Unit, Jesús Usón Minimally Invasive Surgery Centre, Caceres, Spain.
  • Chaushu G; Department of Oral and Maxillofacial Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel.
J Periodontol ; 92(3): 436-445, 2021 03.
Article en En | MEDLINE | ID: mdl-32777099
BACKGROUND: Peri-implant disease (PID) has not been directly linked to pathological organ changes. The present study assessed the dynamics of serum biochemical parameters in a model of experimental peri-implantitis in dogs, followed by open flap debridement. METHODS: Seven male beagle dogs comprised the study group. Procedures were performed as follows-extractions of two premolars and one molar on each mandibular quadrant (Day 0); bone healing time (week14); placement of four rough-surface endoosseous implants, two on each mandibular side; implant uncovering (week 28); induction of experimental peri-implantitis by the use of three ligatures (weeks 31, 34, 37) followed by open flap debridement (week 42). Serum biochemical analysis following each procedure was compared to baseline. Biochemical parameters were assigned into four subsets of variables-inflammation, renal function, liver function, and blood glucose. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure RESULTS: Following experimental peri-implantitis, the dynamics of renal parameters and blood glucose were minimal whereas statistically significant (P < 0.05) increases were noted for inflammatory (total protein and albumin concentrations) and hepatic (ALT, AST) parameters. A statistically significant (P < 0.05) decrease was only noted for total bilirubin. After open flap debridement, inflammatory (total protein and albumin concentrations) and hepatic (AST) parameters returned to baseline. CONCLUSIONS: Within their limits, the present results indicate that: (a) PID affects inflammatory and hepatic serum biochemical parameters, and (b) following open flap debridement most of the values returned to baseline.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantes Dentales / Periimplantitis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Periodontol Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantes Dentales / Periimplantitis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Periodontol Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos