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Efficacy of drug-coated balloon angioplasty after directional coronary atherectomy for coronary bifurcation lesions (DCA/DCB registry).
Kitani, Shunsuke; Igarashi, Yasumi; Tsuchikane, Etsuo; Nakamura, Shigeru; Seino, Yoshitane; Habara, Maoto; Takeda, Yoshihiro; Shimoji, Kenichiro; Yasaka, Yoshinori; Kijima, Mikihiro.
Afiliación
  • Kitani S; Department of Cardiology, Tokeidai Memorial Hospital, Hokkaido, Japan.
  • Igarashi Y; Department of Cardiology, Tokeidai Memorial Hospital, Hokkaido, Japan.
  • Tsuchikane E; Department of Cardiovascular Medicine, Toyohashi Heart Center, Aichi, Japan.
  • Nakamura S; Cardiovascular Center, Kyoto Katsura Hospital, Kyoto, Japan.
  • Seino Y; Cardiology and Vascular Medicine, Hoshi General Hospital, Fukushima, Japan.
  • Habara M; Department of Cardiovascular Medicine, Toyohashi Heart Center, Aichi, Japan.
  • Takeda Y; Department of Cardiology, Rinku General Medical Center, Osaka, Japan.
  • Shimoji K; Department of Cardiology, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
  • Yasaka Y; Department of Cardiology, Hyogo Brain and Heart Center, Hyogo, Japan.
  • Kijima M; Cardiology and Vascular Medicine, Hoshi General Hospital, Fukushima, Japan.
Catheter Cardiovasc Interv ; 97(5): E614-E623, 2021 04 01.
Article en En | MEDLINE | ID: mdl-32776689
OBJECTIVES: To evaluate the efficacy and safety of additional drug-coated balloon (DCB) angioplasty after directional coronary atherectomy (DCA) for coronary bifurcation lesions. BACKGROUND: The optimal therapy for bifurcation lesions has not been established, even in the drug-eluting stent era. DCA possibly prevents plaque and carina shift in bifurcation lesions by plaque debulking; however, the efficacy of combined DCA and DCB (DCA/DCB) for bifurcation lesions remains unclear. METHODS: This multicenter registry retrospectively recruited patients with bifurcation lesions who underwent DCA/DCB and follow-up angiogram at 6-15 months. The primary endpoint was the 12-month target vessel failure (TVF) rate. The secondary endpoints were procedure-related major complications, major cardiovascular events at 12 months, restenosis at 12 months, target lesion revascularization (TLR) at 12 months, and target vessel revascularization (TVR) at 12 months. RESULTS: We enrolled 129 patients from 16 Japanese centers. One hundred and four lesions (80.6%) were located around the left main trunk bifurcations. No side branch compromise was found intraoperatively. Restenosis was observed in three patients (2.3%) at 12 months. TLR occurred in four patients (3.1%): 3 (2.3%) in the main vessel and 1 (0.8%) in the ostium of the side branch at 12 months. TVF incidence at 12 months was slightly higher in 14 patients (10.9%), and only two patients (1.6%) had symptomatic TVR. One patient (0.8%) had non-target vessel-related myocardial infarction. CONCLUSIONS: Our data suggested that DCA/DCB provided good clinical outcomes and minimal side branch damage and could be an optimal non-stent percutaneous coronary intervention strategy for bifurcation lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Preparaciones Farmacéuticas / Aterectomía Coronaria / Angioplastia de Balón / Reestenosis Coronaria / Stents Liberadores de Fármacos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Catheter Cardiovasc Interv Asunto de la revista: CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Preparaciones Farmacéuticas / Aterectomía Coronaria / Angioplastia de Balón / Reestenosis Coronaria / Stents Liberadores de Fármacos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Catheter Cardiovasc Interv Asunto de la revista: CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos