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Implantable zoledronate-PLGA microcapsules ameliorate alveolar bone loss, gingival inflammation and oxidative stress in an experimental periodontitis rat model.
Yao, Chun; Zhang, Qingqing; Li, Jun; She, Peng; Kong, Fanzhi; Du, Yanxiao; Zhang, Feimin.
Afiliación
  • Yao C; The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
  • Zhang Q; Department of Stomatology, Zhenjiang First People's Hospital, Department of Stomatology, People's Hospital Affiliated to Jiangsu University, Dianli Road, Zhenjiang, China.
  • Li J; The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
  • She P; Department of Stomatology, Jiangning Hospital Affiliated to Nanjing Medicine University, Nanjing, China.
  • Kong F; The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
  • Du Y; Department of Stomatology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
  • Zhang F; Department of Stomatology, Zhenjiang First People's Hospital, Department of Stomatology, People's Hospital Affiliated to Jiangsu University, Dianli Road, Zhenjiang, China.
J Biomater Appl ; 35(6): 569-578, 2021 01.
Article en En | MEDLINE | ID: mdl-32772779
The effect of implantable Zoledronate-PLGA microcapsules (PLGA-ZOL) in periodontitis remains unclear. In this study, we aimed to explore the potential role of PLGA-ZOL in protecting periodontitis and elucidate the underlying mechanism. A rat model of periodontitis was established by ligation the mandibular first molars, then PLGA-ZOL was implanted. The healing volume was scanned by cone-beam computed tomography. Cytokine levels in the gingival tissues were determined by ELISA and RT-PCR. Oxidative stress was indicated by detecting superoxide dismutase concentration and catalase activity. After periodontitis model was successfully established in rats, PLGA-ZOL treatment significantly attenuated alveolar bone loss, as indicated by the increased total healing volume, bone volume/tissue volume and osteoprotegerin level, as well as decreased sRANKL level. PLGA-ZOL treatment also suppressed the inflammatory activities by inhibiting pro-inflammatory cytokine production (TNF-α, IL-1ß) but increasing anti-inflammatory cytokine secretion (IL-10). Furthermore, PLGA-ZOL was found to ameliorate oxidative stress in gingival tissues. In conclusion, PLGA-ZOL microcapsules ameliorate alveolar bone loss, gingival inflammation and oxidative stress in an experimental rat model of periodontitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cápsulas / Pérdida de Hueso Alveolar / Copolímero de Ácido Poliláctico-Ácido Poliglicólico / Ácido Zoledrónico / Inflamación / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cápsulas / Pérdida de Hueso Alveolar / Copolímero de Ácido Poliláctico-Ácido Poliglicólico / Ácido Zoledrónico / Inflamación / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido