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Association Between Pretreatment Sleep Disturbance and Radiation Therapy-Induced Pain in 573 Women With Breast Cancer.
Peoples, Anita R; Pigeon, Wilfred R; Li, Dongmei; Garland, Sheila N; Perlis, Michael L; Inglis, Julia E; Vinciguerra, Vincent; Anderson, Thomas; Evans, Lisa S; Wade, James L; Ossip, Deborah J; Morrow, Gary R; Wolf, Julie Ryan.
Afiliación
  • Peoples AR; Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, New York, USA. Electronic address: anita.peoples@hci.utah.edu.
  • Pigeon WR; Department of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York, USA.
  • Li D; Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, New York, USA.
  • Garland SN; Departments of Psychology and Oncology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
  • Perlis ML; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Inglis JE; Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
  • Vinciguerra V; Northwell Health NCORP, Lake Success, New York, USA.
  • Anderson T; Columbus NCORP, Columbus, Ohio, USA.
  • Evans LS; Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem, North Carolina, USA.
  • Wade JL; Heartland Cancer Research NCORP, Decatur, Illinois, USA.
  • Ossip DJ; Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, New York, USA; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York, USA.
  • Morrow GR; Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
  • Wolf JR; Departments of Dermatology and Radiation Oncology, University of Rochester Medical Center, Rochester, New York, USA.
J Pain Symptom Manage ; 61(2): 254-261, 2021 02.
Article en En | MEDLINE | ID: mdl-32768555
CONTEXT: Pain can be a debilitating side effect of radiation therapy (RT). Data from the general population have shown that sleep disturbance can influence pain incidence and severity; however, less is known about this relationship in patients with breast cancer receiving RT. OBJECTIVES: This secondary analysis examined the association of pretreatment moderate/severe levels of sleep disturbance with subsequent RT-induced pain after adjusting for pre-RT pain. METHODS: We report on 573 female patients with breast cancer undergoing RT from a previously completed Phase II clinical trial for radiation dermatitis. Sleep disturbance, total pain, and pain subdomains-sensory pain, affective pain, and perceived pain intensity were assessed at pre-RT and post-RT. At pre-RT, patients were dichotomized into two groups: those with moderate/severe sleep disturbance (N = 85) vs. those with no/mild sleep disturbance (control; N = 488). RESULTS: At pre-RT, women with moderate/severe sleep disturbance were younger, less likely to be married, more likely to have had mastectomy and chemotherapy, and more likely to have depression/anxiety disorder and fatigue than the control group (all Ps < 0.05). Generalized estimating equations model, after controlling for pre-RT pain and other covariates (e.g., trial treatment condition and covariates that were significantly correlated with post-RT pain), showed that women with moderate/severe sleep disturbance at pre-RT vs. control group had significantly higher mean post-RT total pain as well as sensory, affective, and perceived pain (effect size = 0.62, 0.60, 0.69, and 0.52, respectively; all Ps < 0.05). CONCLUSION: These findings suggest that moderate/severe disturbed sleep before RT is associated with increased pain from pre-to-post-RT in patients with breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Neoplasias de la Mama Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Pain Symptom Manage Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Neoplasias de la Mama Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Pain Symptom Manage Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos