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Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28.
Satoh, Ryosuke; Hamada, Naoya; Yamada, Ami; Kanda, Yuki; Ishikawa, Fumihiro; Takasaki, Teruaki; Tanabe, Genzoh; Sugiura, Reiko.
Afiliación
  • Satoh R; Laboratory of Molecular Pharmacogenomics, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: satohr@phar.kindai.ac.jp.
  • Hamada N; Laboratory of Molecular Pharmacogenomics, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: 1933420001u@kindai.ac.jp.
  • Yamada A; Laboratory of Organic Chemistry, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: 1511610091j@kindai.ac.jp.
  • Kanda Y; Laboratory of Molecular Pharmacogenomics, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: 1745110004k@kindai.ac.jp.
  • Ishikawa F; Laboratory of Organic Chemistry, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: ishikawa@phar.kindai.ac.jp.
  • Takasaki T; Laboratory of Molecular Pharmacogenomics, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: takasaki@phar.kindai.ac.jp.
  • Tanabe G; Laboratory of Organic Chemistry, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: g-tanabe@phar.kindai.ac.jp.
  • Sugiura R; Laboratory of Molecular Pharmacogenomics, Faculty of Pharmacy, Kindai University, Kowakae 3-4-1, Higashiosaka City, Osaka 577-8502, Japan. Electronic address: sugiurar@phar.kindai.ac.jp.
Bioorg Chem ; 103: 104137, 2020 10.
Article en En | MEDLINE | ID: mdl-32763519
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Carbonatos / Quinasas MAP Reguladas por Señal Extracelular / Ésteres / Descubrimiento de Drogas / Melanoma / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Carbonatos / Quinasas MAP Reguladas por Señal Extracelular / Ésteres / Descubrimiento de Drogas / Melanoma / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos