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Cocaine attenuates acid sphingomyelinase activity during establishment of addiction-related behavior-A translational study in rats and monkeys.
Frankowska, Malgorzata; Jesus, Fernando M; Mühle, Christiane; Pacheco, Jéssica V N; Maior, Rafael S; Sadakierska-Chudy, Anna; Smaga, Irena; Piechota, Marcin; Kalinichenko, Liubov S; Gulbins, Erich; Kornhuber, Johannes; Filip, Malgorzata; Müller, Christian P; Barros, Marilia.
Afiliación
  • Frankowska M; Department of Drug Addiction Pharmacology, Polish Academy of Sciences, Maj Institute of Pharmacology, Krakow, Poland.
  • Jesus FM; Department of Pharmacy, School of Health Sciences, University of Brasilia, Brasilia, Brazil.
  • Mühle C; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Pacheco JVN; Department of Pharmacy, School of Health Sciences, University of Brasilia, Brasilia, Brazil.
  • Maior RS; Department of Physiological Sciences, University of Brasília, Brasilia, Brazil.
  • Sadakierska-Chudy A; Primate Center, Institute of Biology, University of Brasilia, Brasilia, Brazil.
  • Smaga I; Department of Drug Addiction Pharmacology, Polish Academy of Sciences, Maj Institute of Pharmacology, Krakow, Poland.
  • Piechota M; Department of Drug Addiction Pharmacology, Polish Academy of Sciences, Maj Institute of Pharmacology, Krakow, Poland.
  • Kalinichenko LS; Department of Molecular Neuropharmacology, Polish Academy of Sciences, Maj Institute of Pharmacology, Krakow, Poland.
  • Gulbins E; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Kornhuber J; Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
  • Filip M; Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA.
  • Müller CP; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Barros M; Department of Drug Addiction Pharmacology, Polish Academy of Sciences, Maj Institute of Pharmacology, Krakow, Poland.
Addict Biol ; 26(3): e12955, 2021 05.
Article en En | MEDLINE | ID: mdl-32761719
Cocaine addiction is a severe psychiatric condition for which currently no effective pharmacotherapy is available. Brain mechanisms for the establishment of addiction-related behaviors are still not fully understood, and specific biomarkers for cocaine use are not available. Sphingolipids are major membrane lipids, which shape neuronal membrane composition and dynamics in the brain. Here, we investigated how chronic cocaine exposure during establishment of addiction-related behaviors affects the activity of the sphingolipid rheostat controlling enzymes in the brain of rats. As we detected specific effects on several enzymes in the brain, we tested whether the activity of selected enzymes in the blood may serve as potential biomarker for cocaine exposure in non-human primates (Callithrix penicillata). We found that intravenous cocaine self-administration led to a reduced mRNA expression of Cers1, Degs1 and Degs2, and Smpd1 in the prefrontal cortex of rats, as well as a reduction of Cers4 expression in the striatum. These effects reversed after 10 days of abstinence. Monkeys showed a robust cocaine-induced place preference (CPP). This coincided with a reduction in blood acid sphingomyelinase (ASM) activity after CPP establishment. This effect normalized after 15 days of abstinence. Altogether, these findings suggest that the establishment of cocaine addiction-related behaviors coincides with changes in the activity of sphingolipid controlling enzymes. In particular, blood ASM levels may serve as a translational biomarker for recent cocaine exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Encéfalo / Cocaína Límite: Animals Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Encéfalo / Cocaína Límite: Animals Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos