What came first, the virus or the egg: Innate immunity during viral coinfections.

Rippee-Brooks, Meagan D; Marcinczyk, Riley N; Lupfer, Christopher R

Rippee-Brooks, Meagan D; Marcinczyk, Riley N; Lupfer, Christopher R.

Afiliación

Rippee-Brooks MD; Springfield-Greene County Health Department, Springfield, MO, USA.
Marcinczyk RN; Department of Biology, Missouri State University, Springfield, MO, USA.
Lupfer CR; Department of Biology, Missouri State University, Springfield, MO, USA.

Immunol Rev ; 297(1): 194-206, 2020 09.

Article en En | MEDLINE | ID: mdl-32761626

RESUMEN

Infections with any pathogen can be severe and present with numerous complications caused by the pathogen or the host immune response to the invading microbe. However, coinfections, also called polymicrobial infections or secondary infections, can further exacerbate disease. Coinfections are more common than is often appreciated. In this review, we focus specifically on coinfections between viruses and other viruses, bacteria, parasites, or fungi. Importantly, innate immune signaling and innate immune cells that facilitate clearance of the initial viral infection can affect host susceptibility to coinfections. Understanding these immune imbalances may facilitate better diagnosis, prevention, and treatment of such coinfections.

Asunto(s)

Coinfección; Virosis; Virus; Bacterias; Humanos; Inmunidad Innata

Palabras clave

coinfection; immune signaling; inflammation; innate immunity; polymicrobial infection; secondary infection

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Virosis / Coinfección Límite: Humans Idioma: En Revista: Immunol Rev Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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