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Host Adaptation Predisposes Pseudomonas aeruginosa to Type VI Secretion System-Mediated Predation by the Burkholderia cepacia Complex.
Perault, Andrew I; Chandler, Courtney E; Rasko, David A; Ernst, Robert K; Wolfgang, Matthew C; Cotter, Peggy A.
Afiliación
  • Perault AI; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Chandler CE; Department of Microbial Pathogenesis, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
  • Rasko DA; Institute for Genome Sciences, University of Maryland, Baltimore, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
  • Ernst RK; Department of Microbial Pathogenesis, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
  • Wolfgang MC; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Marsio Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Cotter PA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: peggy_cotter@med.unc.edu.
Cell Host Microbe ; 28(4): 534-547.e3, 2020 10 07.
Article en En | MEDLINE | ID: mdl-32755549
Pseudomonas aeruginosa and Burkholderia cepacia complex (Bcc) species are opportunistic lung pathogens of cystic fibrosis (CF) patients. While P. aeruginosa can initiate long-term infections in younger CF patients, Bcc infections only arise in teenagers and adults. Both P. aeruginosa and Bcc use type VI secretion systems (T6SSs) to mediate interbacterial competition. Here, we show P. aeruginosa isolates from teenage and adult CF patients, but not those from young CF patients, are outcompeted by the epidemic Bcc isolate Burkholderia cenocepacia strain AU1054 in a T6SS-dependent manner. The genomes of susceptible P. aeruginosa isolates harbor T6SS-abrogating mutations, the repair of which, in some cases, rendered the isolates resistant. Moreover, seven of eight Bcc strains outcompeted P. aeruginosa strains isolated from the same patients. Our findings suggest certain mutations that arise as P. aeruginosa adapts to the CF lung abrogate T6SS activity, making P. aeruginosa and its human host susceptible to potentially fatal Bcc superinfection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Complejo Burkholderia cepacia / Interacciones Huésped-Patógeno / Coinfección / Sistemas de Secreción Tipo VI / Adaptación al Huésped Límite: Adolescent / Adult / Animals / Child / Child, preschool / Humans / Infant Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Complejo Burkholderia cepacia / Interacciones Huésped-Patógeno / Coinfección / Sistemas de Secreción Tipo VI / Adaptación al Huésped Límite: Adolescent / Adult / Animals / Child / Child, preschool / Humans / Infant Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos