Your browser doesn't support javascript.
loading
Multiple DNA viruses identified in multimammate mouse (Mastomys natalensis) populations from across regions of sub-Saharan Africa.
Calvignac-Spencer, Sébastien; Kouadio, Léonce; Couacy-Hymann, Emmanuel; Sogoba, Nafomon; Rosenke, Kyle; Davison, Andrew J; Leendertz, Fabian; Jarvis, Michael A; Feldmann, Heinz; Ehlers, Bernhard.
Afiliación
  • Calvignac-Spencer S; P3 "Viral Evolution", Robert Koch-Institute, Berlin, Germany.
  • Kouadio L; LANADA/Central Laboratory for Animal Diseases, Bingerville, Côte d'Ivoire.
  • Couacy-Hymann E; P3 "Epidemiology of Highly Pathogenic Microorganisms", Robert Koch-Institute, Berlin, Germany.
  • Sogoba N; LANADA/Central Laboratory for Animal Diseases, Bingerville, Côte d'Ivoire.
  • Rosenke K; Faculty of Medicine and Odontostomatology, Malaria Research and Training Center, International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Davison AJ; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Leendertz F; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Jarvis MA; P3 "Epidemiology of Highly Pathogenic Microorganisms", Robert Koch-Institute, Berlin, Germany.
  • Feldmann H; School of Biomedical Sciences, University of Plymouth, Plymouth, UK.
  • Ehlers B; The Vaccine Group Ltd, Plymouth, UK.
Arch Virol ; 165(10): 2291-2299, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32754877
The multimammate mouse (Mastomys natalensis; M. natalensis) serves as the main reservoir for the zoonotic arenavirus Lassa virus (LASV), and this has led to considerable investigation into the distribution of LASV and other related arenaviruses in this host species. In contrast to the situation with arenaviruses, the presence of other viruses in M. natalensis remains largely unexplored. In this study, herpesviruses and polyomaviruses were identified and partially characterized by PCR methods, sequencing, and phylogenetic analysis. In tissues sampled from M. natalensis populations in Côte d'Ivoire and Mali, six new DNA viruses (four betaherpesviruses, one gammaherpesvirus and one polyomavirus) were identified. Phylogenetic analysis based on glycoprotein B amino acid sequences showed that the herpesviruses clustered with cytomegaloviruses and rhadinoviruses of multiple rodent species. The complete circular genome of the newly identified polyomavirus was amplified by PCR. Amino acid sequence analysis of the large T antigen or VP1 showed that this virus clustered with a known polyomavirus from a house mouse (species Mus musculus polyomavirus 1). These two polyomaviruses form a clade with other rodent polyomaviruses, and the newly identified virus represents the third known polyomavirus of M. natalensis. This study represents the first identification of herpesviruses and the discovery of a novel polyomavirus in M. natalensis. In contrast to arenaviruses, we anticipate that these newly identified viruses represent a low zoonotic risk due to the normally highly restricted specificity of members of these two DNA virus families to their individual mammalian host species.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Enfermedades de los Roedores / Genoma Viral / Poliomavirus / Infecciones por Herpesviridae / Infecciones por Polyomavirus / Herpesviridae Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Arch Virol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Austria
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Enfermedades de los Roedores / Genoma Viral / Poliomavirus / Infecciones por Herpesviridae / Infecciones por Polyomavirus / Herpesviridae Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Arch Virol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Austria