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Skin transferability of phthalic acid ester plasticizers and other plasticizers using model polyvinyl chloride sheets.
Kawakami, Tsuyoshi; Isama, Kazuo; Jinno, Hideto.
Afiliación
  • Kawakami T; Division of Environmental Chemistry, National Institute of Health Sciences, Kawasaki city, Kanagawa, Japan.
  • Isama K; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
  • Jinno H; Faculty of Pharmaceutical Sciences, Meijo University, Nagoya city, Aichi, Japan.
J Environ Sci Health A Tox Hazard Subst Environ Eng ; 55(10): 1163-1172, 2020.
Article en En | MEDLINE | ID: mdl-32748726
The transferability of phthalic acid esters (PAEs) and other plasticizers, from model polyvinyl chloride (PVC) sheets to the skin of 11 subjects was assessed by measuring the amount of substance transferred using PVC sheets containing PAEs and alternative plasticizers of different types and contents. For all subjects, the transferred amount, from sheets containing 28 wt% PAE or from mixed sheets containing 14 wt% each of di (2-ethylhexyl) phthalate (DEHP) and other PAE, was greater than that from sheets containing 15 wt% each of PAE or alternative plasticizer only. A comparison of the transferability of five types of PAE showed that transfer tended to occur more readily as the n-octanol-water partition coefficient increased, suggesting that PAE hydrophobicity affected its transferability. The transferability of the alternative plasticizers di(2-ethylhexyl) terephthalate and 1,2-cyclohexane dicarboxylic acid diisononyl ester showed a similar trend; however, the transferred amount tended to be higher from model PVC sheets containing 28 wt% PAE or mixed with DEHP. The transferability of PAEs and alternative plasticizers was higher for certain subjects, suggesting individual differences in the transferability of chemicals to the subject's skin surface and is the presence of a group of people comparatively more susceptible to such transfer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plastificantes / Cloruro de Polivinilo / Piel / Absorción Cutánea / Dietilhexil Ftalato / Modelos Biológicos Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Environ Sci Health A Tox Hazard Subst Environ Eng Asunto de la revista: TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plastificantes / Cloruro de Polivinilo / Piel / Absorción Cutánea / Dietilhexil Ftalato / Modelos Biológicos Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Environ Sci Health A Tox Hazard Subst Environ Eng Asunto de la revista: TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido