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The interplay between immunosenescence and age-related diseases.
Barbé-Tuana, Florencia; Funchal, Giselle; Schmitz, Carine Raquel Richter; Maurmann, Rafael Moura; Bauer, Moisés E.
Afiliación
  • Barbé-Tuana F; Laboratory of Immunobiology, Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Funchal G; Laboratory of Immunobiology, Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Schmitz CRR; Graduate Program in Cell Biology: Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Maurmann RM; Laboratory of Immunobiology, Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Bauer ME; Laboratory of Immunobiology, Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. mebauer@pucrs.br.
Semin Immunopathol ; 42(5): 545-557, 2020 10.
Article en En | MEDLINE | ID: mdl-32747977
The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28-), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunosenescencia Tipo de estudio: Prognostic_studies Límite: Aged / Humans Idioma: En Revista: Semin Immunopathol Asunto de la revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunosenescencia Tipo de estudio: Prognostic_studies Límite: Aged / Humans Idioma: En Revista: Semin Immunopathol Asunto de la revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania