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Impact of Diabetes Mellitus and Frailty on Long-Term Outcomes in Elderly Patients with Acute Coronary Syndromes.
Rodríguez-Queraltó, O; Formiga, F; Carol, A; Llibre, C; Martínez-Sellés, M; Marín, F; Díez-Villanueva, P; Sanchis, J; Bonanad, C; Corbí, M; Aboal, J; Angel Perez-Rivera, J; Alegre, O; Bernal, E; Vicent, L; Ariza-Solé, A.
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  • Rodríguez-Queraltó O; Albert Ariza Solé. Cardiology Department. Bellvitge University Hospital, Feixa Llarga s/n. 08907. L'Hospitalet de Llobregat. Barcelona. Spain, Email address: aariza@bellvitgehospital.cat, Fax Number +34932607618; Telephone number +34932607924.
J Nutr Health Aging ; 24(7): 723-729, 2020.
Article en En | MEDLINE | ID: mdl-32744568
OBJECTIVES: Diabetes mellitus (DM) and frailty are common in older patients with acute coronary syndromes (ACS). No data exists about its prognostic impact on long-term outcomes and their possible interaction in this setting. DESIGN: Observational prospective study. SETTING: Multicenter registry conducted in 44 hospitals in Spain. PARTICIPANTS: Consecutive patients with ACS aged 80≥years. MEASUREMENTS: A comprehensive geriatric evaluation was performed during hospitalization, including frailty assessment by the FRAIL score. The impact of DM and frailty on the incidence of mortality/readmission at 24 months was analysed by a Cox regression model. RESULTS: A total of 498 patients were included (mean age 84.3 years). Prevalence of previous DM was 199/498 (40.0%). The rate of frail patients was 135/498 (27.1%). The incidence of mortality/readmission was higher frail patients (HR 2.49) (both p<0.001). In contrast, DM was not significantly associated to a higher rate of outcomes (HR 1.23, p=0.060) in the whole cohort. Among non-frail patients, patients with DM had a similar incidence of mortality or readmission (p=0.959). In contrast, among frail patients, DM was significantly associated with a higher incidence of events (HR 1.51, p=0.034). CONCLUSIONS: Unlike frailty status, DM was not associated to poorer long-term outcome in elderly patients with ACS. Among frail patients the presence of DM seems to provide additional prognostic information.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anciano Frágil / Diabetes Mellitus / Síndrome Coronario Agudo / Fragilidad Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: J Nutr Health Aging Asunto de la revista: CIENCIAS DA NUTRICAO / GERIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anciano Frágil / Diabetes Mellitus / Síndrome Coronario Agudo / Fragilidad Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: J Nutr Health Aging Asunto de la revista: CIENCIAS DA NUTRICAO / GERIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Francia