IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra).

Conti, P; Caraffa, Al; Gallenga, C E; Ross, R; Kritas, S K; Frydas, I; Younes, A; Di Emidio, P; Ronconi, G; Toniato, E

Conti, P; Caraffa, Al; Gallenga, C E; Ross, R; Kritas, S K; Frydas, I; Younes, A; Di Emidio, P; Ronconi, G; Toniato, E.

Afiliación

Conti P; Postgraduate Medical School, University of Chieti, 66013 Chieti, Italy.
Caraffa A; School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Gallenga CE; Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, 44121 Ferrara, Italy.
Ross R; University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Kritas SK; Department of Microbiology, University of Thessaloniki, 54124 Thessaloniki, Greece.
Frydas I; School of Veterinary Medicine, University of Thessaloniki, 54124 Thessaloniki, Greece.
Younes A; Centro Medico "Mai più Dolore", 65100 Pescara, Italy.
Di Emidio P; Maxillofacial Surgery "G. Mazzini" Hospital, 64100 Teramo, Italy.
Ronconi G; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00100 Roma, Italy.
Toniato E; Department of Medical, Oral and Biotechnological Sciences, University of Chieti, Chieti, Italy.

J Biol Regul Homeost Agents ; 34(5): 1623-1627, 2020.

Article en En | MEDLINE | ID: mdl-32744052

Asunto(s)

Infecciones por Coronavirus/patología; Inflamación/virología; Proteína Antagonista del Receptor de Interleucina 1/uso terapéutico; Interleucina-1/fisiología; Neumonía Viral/patología; Trombosis/virología; Tromboxano A2/fisiología; Animales; Betacoronavirus; COVID-19; Humanos; Pandemias; Receptores de Interleucina-1; SARS-CoV-2

Palabras clave

COVID-19; IL-1; SARS-CoV-2; inflammation; thrombosis; thromboxane

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Trombosis / Tromboxano A2 / Interleucina-1 / Infecciones por Coronavirus / Proteína Antagonista del Receptor de Interleucina 1 / Inflamación Límite: Animals / Humans Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia

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