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National Trends and Outcomes of Nonautoimmune Hemolytic Anemia in Alcoholic Liver Disease: Analysis of the Nationwide Inpatient Sample.
Tariq, Tooba; Karabon, Patrick; Irfan, Furqan B; Sieloff, Eric M; Patterson, Rachel; Desai, Archita P.
Afiliación
  • Tariq T; Departments of Geriatric Medicine.
  • Karabon P; Oakland University William Beaumont School of Medicine, Detroit.
  • Irfan FB; College of Osteopathic Medicine, Michigan State University, East Lansing.
  • Sieloff EM; Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo.
  • Patterson R; Oakland University William Beaumont School of Medicine, Rochester, MI.
  • Desai AP; Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.
J Clin Gastroenterol ; 55(3): 258-262, 2021 03 01.
Article en En | MEDLINE | ID: mdl-32740099
GOAL: The aim of this study was to determine the burden of nonautoimmune hemolytic anemia (NAHA) in hospitalized patients with coexisting alcoholic liver disease (ALD), identify risk factors for NAHA in ALD and describe the hospitalization outcomes. BACKGROUND: ALD can result in structural and metabolic alterations in the red-blood cell membrane leading to premature destruction of erythrocytes and hemolytic anemia of varying severity. STUDY: Hospitalized ALD patients with concomitant NAHA were identified in the Nationwide Inpatient Sample database using International Classification of Diseases-9 codes from 2009 to 2014. The primary outcome was to determine the nationwide prevalence and risk factors of NAHA in patients hospitalized with ALD. RESULTS: The prevalence of NAHA was 0.17% (n=3585) among all ALD patients (n=2,125,311) that were hospitalized. Multivariate analysis indicated higher odds of NAHA in ALD patients in the following groups: female gender [adjusted odds ratio (AOR) AOR 1.80, P<0.0001]; highest quartile of median household income (AOR 1.88, P<0.0001); increasing Charlson-Deyo Comorbidity Index (3 to 4 vs. 0, AOR 2.16, P=0.0042) and cirrhosis (AOR 2.74, P<0.0001). Discharges of ALD with anemia had a significantly longer average length of stay (8.8 vs. 6.0 d, P<0.0001), increased hospital charges ($38,961 vs. $25,244, P<0.0001) and higher mortality (9.0% vs. 5.6%, P<0.0001) when compared with ALD with no anemia. CONCLUSION: NAHA in patients with ALD is an important prognostic marker, predicting a longer, costlier hospitalization and increased inpatient mortality in ALD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anemia Hemolítica / Hepatopatías Alcohólicas Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: J Clin Gastroenterol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anemia Hemolítica / Hepatopatías Alcohólicas Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: J Clin Gastroenterol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos