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Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis.
Pek, Jen Heng; Gan, Ming Ying; Yap, Bei Jun; Seethor, Shu Ting Tammie; Greenberg, Rachel G; Hornik, Christoph Paul Vincent; Tan, Bobby; Lee, Jan Hau; Chong, Shu-Ling.
Afiliación
  • Pek JH; Emergency Medicine, Sengkang General Hospital, Singapore.
  • Gan MY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Yap BJ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Seethor STT; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Greenberg RG; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
  • Hornik CPV; Division of Critical Care Medicine, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
  • Tan B; Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
  • Lee JH; Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore.
  • Chong SL; Department of Emergency Medicine, KK Women's and Children's Hospital, Singapore chong.shu-ling@kkh.com.sg.
BMJ Open ; 10(7): e038815, 2020 07 31.
Article en En | MEDLINE | ID: mdl-32737098
INTRODUCTION: Neonatal sepsis has a high mortality rate that varies across different populations. We aim to perform a contemporary global evidence synthesis to determine the case fatality rates of neonatal sepsis, in order to better delineate this public health urgency and inform strategies to reduce fatality in this high-risk population. METHODS AND ANALYSIS: We will search PubMed, Cochrane Central, Embase and Web of Science for articles in English language published between January 2010 and December 2019. All clinical trials and observational studies involving infants less than 90 days old with a clinical diagnosis of sepsis and reported case fatality rate will be included. Two independent reviewers will screen the studies and extract data on study variables chosen a priori. Quality of evidence and risk of bias will be assessed using Cochrane Collaboration's tool and ROBINS-I. Results will be synthesised qualitatively and pooled for meta-analysis. ETHICS AND DISSEMINATION: No formal ethical approval is required as there is no collection of primary data. This systematic review and meta-analysis will be disseminated through conference meetings and peer-reviewed publications. PROSPERO REGISTRATION NUMBER: CRD42020164321.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sepsis / Sepsis Neonatal Tipo de estudio: Observational_studies / Systematic_reviews Aspecto: Ethics Límite: Humans / Infant / Newborn Idioma: En Revista: BMJ Open Año: 2020 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sepsis / Sepsis Neonatal Tipo de estudio: Observational_studies / Systematic_reviews Aspecto: Ethics Límite: Humans / Infant / Newborn Idioma: En Revista: BMJ Open Año: 2020 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido