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Gastrointestinal manifestations of angioedema: a potential area of misdiagnosis.
Mormile, Ilaria; Cocchiaro, Antonio; Bova, Maria; Loffredo, Stefania; de Paulis, Amato; Spadaro, Giuseppe; Petraroli, Angelica.
Afiliación
  • Mormile I; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence.
  • Cocchiaro A; Post-Graduate Program in Clinical Immunology and Allergy, University of Naples Federico II.
  • Bova M; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence.
  • Loffredo S; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence.
  • de Paulis A; Institute of Experimental Endocrinology and Oncology 'G. Salvatore' (IEOS), National Research Council (CNR), Naples, Italy.
  • Spadaro G; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence.
  • Petraroli A; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence.
Eur J Gastroenterol Hepatol ; 33(6): 787-793, 2021 06 01.
Article en En | MEDLINE | ID: mdl-32732812
Abdominal pain is one of the most common conditions leading people to the emergency department. An uncommon but well described cause of abdominal pain is angioedema of the gastrointestinal tract due to recurrent angioedema without wheals. Abdominal involvement is very common in hereditary angioedema (HAE), but it is also described in acquired angioedema and allergic forms. In patients with HAE, the involvement of gastrointestinal tract with resultant abdominal pain occurs in 43-93% of cases. Attacks can involve the entire gastrointestinal tract, such as the oropharynx, small intestine, colon, liver, or pancreas. Pain is the most common gastrointestinal symptom, and it may occur for many years even without cutaneous or respiratory symptoms. The case report we included in this article emphasizes the importance of accurate evaluation of personal and family history in patients with a long history of acute, severe, and unexplained abdominal pain, and it gives an example of how diagnostic delay may be longer if gastroenterological symptoms are the predominant clinical presentation. Furthermore, sometimes the simultaneous presence of concomitant gastrointestinal disorders and HAE may cause difficulties in differential diagnosis. Gastroenterologists and other physicians should add HAE to their list of potential causes of unexplained abdominal pain. The initiation of appropriate prophylaxis and treatment will prevent needless suffering and useless surgical and medical procedures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioedemas Hereditarios / Angioedema Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Eur J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioedemas Hereditarios / Angioedema Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Eur J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido