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Drug-Eluting Stents Versus Bare-Metal Stents in Large Coronary Artery Revascularization: Systematic Review and Meta-Analysis.
Changal, Khalid Hamid; Mir, Tanveer; Khan, Shayan; Nazir, Salik; Elzanatey, Ahmed; Meenakshisundaram, Chandramohan; Mubbasher, Syed; Sheikh, Mujeeb A.
Afiliación
  • Changal KH; Cardiovascular Medicine, University of Toledo Health Sciences, United States of America. Electronic address: khalid.changal@utoledo.edu.
  • Mir T; Internal Medicine, Detroit Medical Center, Wayne State University, United States of America.
  • Khan S; Internal Medicine, Mercy St. Vincent medical Center, Toledo, OH, United States of America.
  • Nazir S; Cardiovascular Medicine, University of Toledo Health Sciences, United States of America.
  • Elzanatey A; Internal Medicine, University of Toledo Health Sciences, United States of America.
  • Meenakshisundaram C; Internal Medicine, University of Toledo Health Sciences, United States of America.
  • Mubbasher S; Cardiovascular Medicine, University of Toledo Health Sciences, United States of America.
  • Sheikh MA; Cardiovascular Medicine and Interventional Cardiology, Promedica Toledo Hospital, United States of America. Electronic address: Smujeeb73@gmail.com.
Cardiovasc Revasc Med ; 23: 42-49, 2021 02.
Article en En | MEDLINE | ID: mdl-32723603
OBJECTIVES: We aim to determine if drug eluting stents (DES) are better than bare-metal stents (BMS) in large coronary artery (diameter ≥ 3 mm) percutaneous coronary intervention (PCI). BACKGROUND: DES have become the standard of care for PCI in coronary artery disease (CAD). However, the superiority of DES over BMS in large vessel CAD is not clear and previous studies have shown conflicting results. METHODS: Randomized controlled trials (RCTs) comparing outcomes of PCI with BMS and DES for large vessel CAD were identified from the year 2000 to August 2019. The outcomes were studied individually and included all-cause mortality, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis. Aggregated odds ratio and 95% CI were calculated using a random-effects model. RESULTS: Eight RCTs were included (4 with data for first-generation DES, 3 with data for second-generation DES, and 1 with data for both first- and second-generation DES). Compared to BMS, second generation DES had a significantly lower rate of all-cause mortality (2.4% vs. 3.9%, OR 0.74, 95% CI 0.56-0.98, P 0.04), TLR (3.5% vs. 8.6% OR 0.38 95% CI 0.28-0.53, P < 0.001), and MI (2.1% vs. 2.9% OR 0.73 95% CI 0.53-1.0, P 0.05). The difference in all-cause mortality was not seen with first-generation DES. CONCLUSION: Newer DES are associated with a lower mortality, TLR, and MI and thus should be preferred over BMS for large coronary artery PCI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Stents Liberadores de Fármacos / Intervención Coronaria Percutánea Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Stents Liberadores de Fármacos / Intervención Coronaria Percutánea Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos