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Evolutionary History of Endogenous Human Herpesvirus 6 Reflects Human Migration out of Africa.
Aswad, Amr; Aimola, Giulia; Wight, Darren; Roychoudhury, Pavitra; Zimmermann, Cosima; Hill, Joshua; Lassner, Dirk; Xie, Hong; Huang, Meei-Li; Parrish, Nicholas F; Schultheiss, Heinz-Peter; Venturini, Cristina; Lager, Susanne; Smith, Gordon C S; Charnock-Jones, D Stephen; Breuer, Judith; Greninger, Alexander L; Kaufer, Benedikt B.
Afiliación
  • Aswad A; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
  • Aimola G; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
  • Wight D; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
  • Roychoudhury P; Department of Laboratory Medicine, University of Washington, Seattle, WA.
  • Zimmermann C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Centre, Seattle, WA.
  • Hill J; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
  • Lassner D; Department of Laboratory Medicine, University of Washington, Seattle, WA.
  • Xie H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Centre, Seattle, WA.
  • Huang ML; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Parrish NF; HighTech Center, Vinmec Hospital, Hanoi, Vietnam.
  • Schultheiss HP; Institut Kardiale Diagnostik und Therapie, Berlin, Germany.
  • Venturini C; Department of Laboratory Medicine, University of Washington, Seattle, WA.
  • Lager S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Centre, Seattle, WA.
  • Smith GCS; Department of Laboratory Medicine, University of Washington, Seattle, WA.
  • Charnock-Jones DS; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Centre, Seattle, WA.
  • Breuer J; Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Greninger AL; Institut Kardiale Diagnostik und Therapie, Berlin, Germany.
  • Kaufer BB; Division of Infection and Immunity, UCL Research Department of Infection, UCL, London, United Kingdom.
Mol Biol Evol ; 38(1): 96-107, 2021 01 04.
Article en En | MEDLINE | ID: mdl-32722766
Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result, ∼70 million people harbor the genome of one of these viruses in every cell of their body. Until now, it has been largely unknown if 1) these integrations are ancient, 2) if they still occur, and 3) whether circulating virus strains differ from integrated ones. Here, we used next-generation sequencing and mining of public human genome data sets to generate the largest and most diverse collection of circulating and integrated HHV-6 genomes studied to date. In genomes of geographically dispersed, only distantly related people, we identified clades of integrated viruses that originated from a single ancestral event, confirming this with fluorescent in situ hybridization to directly observe the integration locus. In contrast to HHV-6B, circulating and integrated HHV-6A sequences form distinct clades, arguing against ongoing integration of circulating HHV-6A or "reactivation" of integrated HHV-6A. Taken together, our study provides the first comprehensive picture of the evolution of HHV-6, and reveals that integration of heritable HHV-6 has occurred since the time of, if not before, human migrations out of Africa.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Herpesvirus Humano 6 / Migración Humana Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Herpesvirus Humano 6 / Migración Humana Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos