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Polymeric micelles for the ocular delivery of triamcinolone acetonide: preparation and in vivo evaluation in a rabbit ocular inflammatory model.
Safwat, Mohamed A; Mansour, Heba F; Hussein, Amal K; Abdelwahab, Soha; Soliman, Ghareb M.
Afiliación
  • Safwat MA; Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, Egypt.
  • Mansour HF; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Hussein AK; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Abdelwahab S; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, Egypt.
  • Soliman GM; Department of Basic Medical Sciences, Deraya University, New Minia, Egypt.
Drug Deliv ; 27(1): 1115-1124, 2020 Dec.
Article en En | MEDLINE | ID: mdl-32720545
The aim of this study was to prepare triamcinolone acetonide (TA)-loaded poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) micelles as a potential treatment of ocular inflammation. The micelles were evaluated for particle size, drug loading capacity and drug release kinetics. Selected micellar formulations were dispersed into chitosan hydrogel and their anti-inflammatory properties were tested in rabbits using a carrageenan-induced ocular inflammatory model. Particle size ranged from 59.44 ± 0.15 to 64.26 ± 0.55 nm for PEG-b-PCL and from 136.10 ± 1.57 to 176.80 ± 2.25 nm for PEG-b-PLA micelles, respectively. The drug loading capacity was in the range of 6-12% and 15-25% for PEG-b-PCL and PEG-b-PLA micelles, respectively and was dependent on the drug/polymer weight ratio. TA aqueous solubility was increased by 5- and 10-fold after loading into PEG-b-PCL and PEG-b-PLA micelles at a polymer concentration as low as 0.5 mg/mL, respectively. PEG-b-PLA micelles suspended in chitosan hydrogel were able to sustain the drug release where only 42.8 ± 1.6% drug was released in one week. TA/PEG-b-PLA micelles suspended in chitosan hydrogel had better anti-inflammatory effects compared with the plain drug hydrogel or the drug micellar solution. Complete disappearance of the corneal inflammatory changes was observed for the micellar hydrogel. These results confirm the potential of PEG-b-PLA micelles suspended in chitosan hydrogel to enhance the anti-inflammatory properties of triamcinolone acetonide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Triamcinolona Acetonida / Oftalmopatías / Inflamación / Lactatos / Lactonas / Antiinflamatorios Límite: Animals Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2020 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Triamcinolona Acetonida / Oftalmopatías / Inflamación / Lactatos / Lactonas / Antiinflamatorios Límite: Animals Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2020 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido