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Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.
Selvadurai, Maria V; Moon, Mitchell J; Mountford, Simon J; Ma, Xiao; Zheng, Zhaohua; Jennings, Ian G; Setiabakti, Natasha M; Iman, Rizani P; Brazilek, Rose J; Z Abidin, Nurul Aisha; Chicanne, Gaëtan; Severin, Sonia; Nicholls, Alyce J; Wong, Connie H Y; Rinckel, Jean-Yves; Eckly, Anita; Gachet, Christian; Nesbitt, Warwick S; Thompson, Philip E; Hamilton, Justin R.
Afiliación
  • Selvadurai MV; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Moon MJ; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Mountford SJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Ma X; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Zheng Z; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Jennings IG; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Setiabakti NM; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Iman RP; Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta 10430, Indonesia.
  • Brazilek RJ; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Z Abidin NA; Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta 10430, Indonesia.
  • Chicanne G; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Severin S; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Nicholls AJ; Institut des Maladies Métaboliques et Cardiovasculaires, Inserm U1048, Université Toulouse III, 31432 Toulouse CEDEX 4, France.
  • Wong CHY; Institut des Maladies Métaboliques et Cardiovasculaires, Inserm U1048, Université Toulouse III, 31432 Toulouse CEDEX 4, France.
  • Rinckel JY; Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC 3800, Australia.
  • Eckly A; Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC 3800, Australia.
  • Gachet C; Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, F-67000 Strasbourg, France.
  • Nesbitt WS; Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, F-67000 Strasbourg, France.
  • Thompson PE; Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, F-67000 Strasbourg, France.
  • Hamilton JR; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
Sci Transl Med ; 12(553)2020 07 22.
Article en En | MEDLINE | ID: mdl-32718993
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Plaquetas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Plaquetas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos