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Supramolecular polyelectrolyte complexes based on cyclodextrin-grafted chitosan and carrageenan for controlled drug release.
Evangelista, Thamasia F S; Andrade, George R S; Nascimento, Keyte N S; Dos Santos, Samuel B; de Fátima Costa Santos, Maria; Da Ros Montes D'Oca, Caroline; Dos S Estevam, Charles; Gimenez, Iara F; Almeida, Luís E.
Afiliación
  • Evangelista TFS; Postgraduate Program in Materials Science and Engineering, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • Andrade GRS; Postgraduate Program in Energy, Federal University of Espírito Santo, São Mateus, ES, Brazil. Electronic address: george.andrade@ufes.br.
  • Nascimento KNS; Postgraduate Program in Materials Science and Engineering, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • Dos Santos SB; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • de Fátima Costa Santos M; Posgraduate Program of Chemistry, NMR Laboratory, Departament of Chemistry, Federal University of Paraná, Curitiba, PR, Brazil.
  • Da Ros Montes D'Oca C; NMR Laboratory, Departament of Chemistry, Federal University of Paraná, Curitiba, PR, Brazil.
  • Dos S Estevam C; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • Gimenez IF; Department of Chemistry, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • Almeida LE; Postgraduate Program in Materials Science and Engineering, Federal University of Sergipe, São Cristóvão, SE, Brazil. Electronic address: edu@ufs.br.
Carbohydr Polym ; 245: 116592, 2020 Oct 01.
Article en En | MEDLINE | ID: mdl-32718656
In the present study, supramolecular polyelectrolyte complexes (SPEC) based on a cyclodextrin-grafted chitosan derivative and carrageenan were prepared and evaluated for controlled drug release. Samples were characterized by FTIR, SEM, and ζ-potential measurements, which confirmed the formation of the polymeric complex. The phenolphthalein test confirmed the presence and availability of inclusion sites from the attached ßCD. Silver sulfadiazine was used as the model drug and the association with the SPEC was studied by FTIR and computational molecular modeling, using a semi-empirical method. DRS and TEM analyses have shown that Ag+ ions from the drug were reduced to form metallic silver nanostructures. In vitro tests have shown a clear bacterial activity toward Gram-positive bacteria Staphylococcus aureus and Enterococcus durans/hirae and Gram-negative bacteria Klebsiella pneumoniae and Escherichia coli. Finally, this work shows that ßCD-chitosan/carrageenan supramolecular polyelectrolyte complexes hold an expressive potential to be applied as a polymer-based system for controlled drug release.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Ciclodextrinas / Quitosano / Liberación de Fármacos / Polielectrolitos / Antibacterianos Idioma: En Revista: Carbohydr Polym Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Ciclodextrinas / Quitosano / Liberación de Fármacos / Polielectrolitos / Antibacterianos Idioma: En Revista: Carbohydr Polym Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido