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Sleep and Microbiome in Psychiatric Diseases.
Wagner-Skacel, Jolana; Dalkner, Nina; Moerkl, Sabrina; Kreuzer, Kathrin; Farzi, Aitak; Lackner, Sonja; Painold, Annamaria; Reininghaus, Eva Z; Butler, Mary I; Bengesser, Susanne.
Afiliación
  • Wagner-Skacel J; Department of Medical Psychology, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Moerkl S; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Kreuzer K; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Farzi A; Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Division of Pharmacology, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Lackner S; Otto Loewi Research Center (for Vascular Biology, Immunology andI), Division of Immunology and Pathophysiology, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Painold A; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Reininghaus EZ; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
  • Butler MI; Department of Psychiatry, University College Cork, T12 YN60 Cork, Ireland.
  • Bengesser S; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
Nutrients ; 12(8)2020 Jul 23.
Article en En | MEDLINE | ID: mdl-32718072
OBJECTIVES: Disturbances in the gut-brain barrier play an essential role in the development of mental disorders. There is considerable evidence showing that the gut microbiome not only affects digestive, metabolic and immune functions of the host but also regulates host sleep and mental states through the microbiota-gut-brain axis. The present review summarizes the role of the gut microbiome in the context of circadian rhythms, nutrition and sleep in psychiatric disorders. METHODS: A PubMed search (studies published between April 2015-April 2020) was conducted with the keywords: "sleep, microbiome and psychiatry"; "sleep, microbiome and depression"; "sleep, microbiome and bipolar disorder", "sleep, microbiome and schizophrenia", "sleep, microbiome and anorexia nervosa", "sleep, microbiome and substance use disorder", "sleep, microbiome and anxiety"; "clock gene expression and microbiome", "clock gene expression and nutrition". Only studies investigating the relationship between sleep and microbiome in psychiatric patients were included in the review. RESULTS: Search results yielded two cross-sectional studies analyzing sleep and gut microbiome in 154 individuals with bipolar disorder and one interventional study analyzing the effect of fecal microbiota transplantation in 17 individuals with irritable bowel syndrome on sleep. In patients with bipolar disorder, Faecalibacterium was significantly associated with improved sleep quality scores and a significant correlation between Lactobacillus counts and sleep. CONCLUSION: Translational research on this important field is limited and further investigation of the bidirectional pathways on sleep and the gut microbiome in mood disorders is warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Microbiota / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Microbiota / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza