Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors.

Yang, Fang; Jian, Xie-Er; Diao, Peng-Cheng; Huo, Xian-Sen; You, Wen-Wei; Zhao, Pei-Liang

Yang, Fang; Jian, Xie-Er; Diao, Peng-Cheng; Huo, Xian-Sen; You, Wen-Wei; Zhao, Pei-Liang.

Afiliación

Yang F; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Jian XE; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Diao PC; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Huo XS; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
You WW; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Zhao PL; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: plzhao@smu.edu.cn.

Eur J Med Chem ; 204: 112625, 2020 Oct 15.

Article en En | MEDLINE | ID: mdl-32717486

Asunto(s)

Piridinas/química; Triazoles/química; Moduladores de Tubulina/síntesis química; Moduladores de Tubulina/farmacología; Apoptosis/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Células HEK293; Células HeLa; Humanos; Concentración 50 Inhibidora; Análisis Espectral/métodos

Palabras clave

Antiproliferative activity; Synthesis; Tubulin polymerization; [1,2,4]triazolo[4,3-a]pyridine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Triazoles / Moduladores de Tubulina Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article Pais de publicación: Francia

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