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Ceftriaxone Relieves Trigeminal Neuropathic Pain Through Suppression of Spatiotemporal Synaptic Plasticity via Restoration of Glutamate Transporter 1 in the Medullary Dorsal Horn.
Luo, Xiao; He, Ting; Wang, Yan; Wang, Jiang-Lin; Yan, Xue-Bin; Zhou, Hao-Cheng; Wang, Rui-Rui; Du, Rui; Wang, Xiao-Liang; Chen, Jun; Huang, Dong.
Afiliación
  • Luo X; Department of Pain Management, The Third Xiangya Hospital, Institute of Pain Medicine, Central South University, Changsha, China.
  • He T; Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
  • Wang Y; Key Laboratory of Brain Stress and Behavior, People's Liberation Army, Xi'an, China.
  • Wang JL; Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
  • Yan XB; Key Laboratory of Brain Stress and Behavior, People's Liberation Army, Xi'an, China.
  • Zhou HC; Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
  • Wang RR; Department of Pain Management, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Du R; Department of Pain Management, The Third Xiangya Hospital, Institute of Pain Medicine, Central South University, Changsha, China.
  • Wang XL; Department of Pain Management, The Third Xiangya Hospital, Institute of Pain Medicine, Central South University, Changsha, China.
  • Chen J; Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
  • Huang D; Key Laboratory of Brain Stress and Behavior, People's Liberation Army, Xi'an, China.
Front Cell Neurosci ; 14: 199, 2020.
Article en En | MEDLINE | ID: mdl-32714151
Using a rat model of trigeminal neuropathic pain (TNP) produced by chronic compression of the infraorbital nerve (CCI-ION), we investigated the analgesic effect and the underlying mechanisms of ceftriaxone (Cef), a ß-lactam antibiotic, that is thought to be a potent stimulator of glutamate transporter 1 (GLT-1). First, repeated intraperitoneal (i.p.) injections of Cef (200 mg/kg) for 5-days since Day 1 of CCI-ION could significantly relieve both mechanical and thermal pain hypersensitivity from day 10 after drug administration. Western blot and immunofluorescent results demonstrated that 5-days administration of Cef resulted in the restoration of GLT-1 expression to a level equivalent to the sham control which was dramatically lost under the TNP condition. Moreover, multi-electrode (8 × 8) array recordings of network field excitatory postsynaptic potentials (fEPSPs) were performed on the acutely dissociated medullary dorsal horn slice evoked by electrical stimulation of the trigeminal spinal tract. The results showed that the increased number of fEPSPs, induction rate, and maintenance of long-term potentiation caused by CCI-ION were significantly suppressed by 5-days administration of Cef. Taken together, the results indicate that Cef can relieve TNP through suppression of spatiotemporal synaptic plasticity via GLT-1 restoration in the medullary dorsal horn of the trigeminal nerve.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Neurosci Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Neurosci Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza