Clinical outcomes of prexasertib monotherapy in recurrent <i>BRCA</i> wild-type high-grade serous ovarian cancer involve innate and adaptive immune responses.

Lampert, Erika J; Cimino-Mathews, Ashley; Lee, Joo Sang; Nair, Jayakumar; Lee, Min-Jung; Yuno, Akira; An, Daniel; Trepel, Jane B; Ruppin, Eytan; Lee, Jung-Min

Clinical outcomes of prexasertib monotherapy in recurrent BRCA wild-type high-grade serous ovarian cancer involve innate and adaptive immune responses.

Lampert, Erika J; Cimino-Mathews, Ashley; Lee, Joo Sang; Nair, Jayakumar; Lee, Min-Jung; Yuno, Akira; An, Daniel; Trepel, Jane B; Ruppin, Eytan; Lee, Jung-Min.

Afiliación

Lampert EJ; Women's Malignancies Branch, National Cancer Institute, Bethesda, Maryland, USA lampere@ccf.org.
Cimino-Mathews A; Department of Pathology, Johns Hopkins, Baltimore, Maryland, USA.
Lee JS; Cancer Data Science Laboratory, National Cancer Institute, Bethesda, Maryland, USA.
Nair J; Women's Malignancies Branch, National Cancer Institute, Bethesda, Maryland, USA.
Lee MJ; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, Maryland, USA.
Yuno A; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, Maryland, USA.
An D; Women's Malignancies Branch, National Cancer Institute, Bethesda, Maryland, USA.
Trepel JB; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, Maryland, USA.
Ruppin E; Cancer Data Science Laboratory, National Cancer Institute, Bethesda, Maryland, USA.
Lee JM; Women's Malignancies Branch, National Cancer Institute, Bethesda, Maryland, USA.

J Immunother Cancer ; 8(2)2020 07.

Article en En | MEDLINE | ID: mdl-32709712

Asunto(s)

Cistadenocarcinoma Seroso/tratamiento farmacológico; Inmunoterapia/métodos; Neoplasias Ováricas/tratamiento farmacológico; Pirazinas/uso terapéutico; Pirazoles/uso terapéutico; Anciano; Cistadenocarcinoma Seroso/patología; Femenino; Humanos; Persona de Mediana Edad; Clasificación del Tumor; Neoplasias Ováricas/patología; Pirazinas/farmacología; Pirazoles/farmacología; Microambiente Tumoral

Palabras clave

adaptive immunity; immunity, innate; immunomodulation; immunotherapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Pirazinas / Pirazoles / Cistadenocarcinoma Seroso / Inmunoterapia Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: J Immunother Cancer Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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