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Accuracy of target delineation by positron emission tomography-based auto-segmentation methods after deformable image registration: A phantom study.
Katayama, Hiroki; Takahashi, Shigeo; Maeda, Yukito; Kobata, Takuya; Oishi, Akihiro; Sasakawa, Yasuhiro; Shibata, Toru.
Afiliación
  • Katayama H; Department of Clinical Radiology, Kagawa University Hospital, Kagawa, Japan; Graduate School of Medicine, Kagawa University, Kagawa, Japan. Electronic address: k-hiroki@med.kagawa-u.ac.jp.
  • Takahashi S; Department of Radiation Oncology, Kagawa University Hospital, Kagawa, Japan.
  • Maeda Y; Department of Clinical Radiology, Kagawa University Hospital, Kagawa, Japan.
  • Kobata T; Department of Clinical Radiology, Kagawa University Hospital, Kagawa, Japan.
  • Oishi A; Department of Clinical Radiology, Kagawa University Hospital, Kagawa, Japan.
  • Sasakawa Y; Department of Clinical Radiology, Kagawa University Hospital, Kagawa, Japan.
  • Shibata T; Department of Radiation Oncology, Kagawa University Hospital, Kagawa, Japan.
Phys Med ; 76: 194-201, 2020 Aug.
Article en En | MEDLINE | ID: mdl-32707483
PURPOSE: Diagnostic positron emission tomography and computed tomography (PET/CT) images can be fused to the planning CT images by a deformable image registration (DIR). The aim of this study was to evaluate the standardized uptake value (SUV) and target delineation on deformed PET images. METHODS: We used a cylindrical phantom and removable inserts of four spheres (16-38 mm in diameter) and three ellipsoids with a volume equal to the 38-mm-diameter sphere (S38) in each. S38 was filled with 18F-fluorodeoxyglucose activity, and then PET/CT images were acquired. The contours of S38 were generated using original PET images by PET auto-segmentation (PET-AS) methods of (1) SUV2.5, (2) 40% of maximum SUV (SUV40%max), and (3) gradient-based (GB), and were deformed to the other inserts by DIR. We compared the volumes and the SUVmax with the generated contours using the deformed PET images. RESULTS: The SUVmax was slightly decreased by DIR; the mean absolute difference was -0.10 ± 0.04. For SUV2.5 and SUV40%max, the differences in S38 volumes between the original and deformed PET images were less than 5%, regardless of deformation type. For the GB, the contoured volumes obtained from deformed PET images were larger than those of the original PET images for the deformation type of ellipsoids. When the S38 was deformed to the 16-mm-diameter sphere, the maximum volume difference was -22.8%. CONCLUSIONS: Although SUV fluctuations by DIR were negligible, the target delineation on deformed PET images by the GB should be carefully considered owing to the distortion of intensity profiles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía de Emisión de Positrones / Tomografía Computarizada por Tomografía de Emisión de Positrones Idioma: En Revista: Phys Med Asunto de la revista: BIOFISICA / BIOLOGIA / MEDICINA Año: 2020 Tipo del documento: Article Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía de Emisión de Positrones / Tomografía Computarizada por Tomografía de Emisión de Positrones Idioma: En Revista: Phys Med Asunto de la revista: BIOFISICA / BIOLOGIA / MEDICINA Año: 2020 Tipo del documento: Article Pais de publicación: Italia