Anti­inflammatory activity of 3,5,6,7,3',4'­hexamethoxyflavone via repression of the NF­&#954;B and MAPK signaling pathways in LPS­stimulated RAW264.7 cells.

Son, Eun Suk; Park, Jeong-Woong; Kim, Se-Hee; Park, Hye Ran; Han, Woorijarang; Kwon, O Chul; Nam, Jae Young; Jeong, Sung Hwan; Lee, Chang Soo

Antiinflammatory activity of 3,5,6,7,3',4'hexamethoxyflavone via repression of the NFκB and MAPK signaling pathways in LPSstimulated RAW264.7 cells.

Son, Eun Suk; Park, Jeong-Woong; Kim, Se-Hee; Park, Hye Ran; Han, Woorijarang; Kwon, O Chul; Nam, Jae Young; Jeong, Sung Hwan; Lee, Chang Soo.

Afiliación

Son ES; Department of Biomedical Chemistry, Konkuk University, Chungju, Chungcheongbuk 27478, Republic of Korea.
Park JW; Department of Allergy, Pulmonary and Critical Care Medicine, Gachon University Gil Medical Center, Incheon 21565, Republic of Korea.
Kim SH; Gachon Medical Research Institute, Gachon University Gil Medical Center, Incheon 21565, Republic of Korea.
Park HR; Company Affiliated Research Institute, Seongnam, Gyeonggi 13511, Republic of Korea.
Han W; Department of Biomedical Chemistry, Konkuk University, Chungju, Chungcheongbuk 27478, Republic of Korea.
Kwon OC; Department of Biomedical Chemistry, Konkuk University, Chungju, Chungcheongbuk 27478, Republic of Korea.
Nam JY; Department of Biomedical Chemistry, Konkuk University, Chungju, Chungcheongbuk 27478, Republic of Korea.
Jeong SH; Department of Allergy, Pulmonary and Critical Care Medicine, Gachon University Gil Medical Center, Incheon 21565, Republic of Korea.
Lee CS; Department of Biomedical Chemistry, Konkuk University, Chungju, Chungcheongbuk 27478, Republic of Korea.

Mol Med Rep ; 22(3): 1985-1993, 2020 09.

Article en En | MEDLINE | ID: mdl-32705181

Asunto(s)

Antiinflamatorios/farmacología; Citrus/química; Flavonas/farmacología; Lipopolisacáridos/efectos adversos; Animales; Dinoprostona/metabolismo; Regulación de la Expresión Génica/efectos de los fármacos; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Ratones; FN-kappa B/metabolismo; Óxido Nítrico Sintasa/metabolismo; Fosforilación/efectos de los fármacos; Extractos Vegetales/química; Células RAW 264.7

Palabras clave

quercetogetin; antiinflammatory; NFκB; ERK; cyclooxygenase2; inducible nitric oxide synthase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Citrus / Flavonas / Antiinflamatorios Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2020 Tipo del documento: Article Pais de publicación: Grecia

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