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Effect of neoadjuvant chemotherapy on health-related quality of life in patients with muscle-invasive bladder cancer: results from JCOG0209, a randomized phase III study.
Kitamura, Hiroshi; Hinotsu, Shiro; Tsukamoto, Taiji; Shibata, Taro; Mizusawa, Junki; Kobayashi, Takashi; Miyake, Makito; Nishiyama, Naotaka; Kojima, Takahiro; Nishiyama, Hiroyuki.
Afiliación
  • Kitamura H; Department of Urology, Faculty of Medicine, University of Toyama, Toyama Toyama, Japan.
  • Hinotsu S; Department of Biostatistics, Sapporo Medical University, SapporoHokkaido, Japan.
  • Tsukamoto T; Department of Urology, Sapporo Medical University School of Medicine, Sapporo Hokkaido, Japan.
  • Shibata T; Japan Clinical Oncology Group Data Center, National Cancer Center Hospital, Tokyo, Japan.
  • Mizusawa J; Japan Clinical Oncology Group Data Center, National Cancer Center Hospital, Tokyo, Japan.
  • Kobayashi T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Miyake M; Department of Urology, Nara Medical University, Kashihara, Nara, Japan.
  • Nishiyama N; Department of Urology, Faculty of Medicine, University of Toyama, Toyama Toyama, Japan.
  • Kojima T; Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Nishiyama H; Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Jpn J Clin Oncol ; 50(12): 1464-1469, 2020 Dec 16.
Article en En | MEDLINE | ID: mdl-32699909
BACKGROUND: Although neoadjuvant chemotherapy provides survival benefits in muscle-invasive bladder cancer, the impact of neoadjuvant chemotherapy on health-related quality of life has not been investigated by a randomized trial. The purpose of this study is to compare health-related quality of life in patients with muscle-invasive bladder cancer who received neoadjuvant chemotherapy followed by radical cystectomy or radical cystectomy alone based on patient-reported outcome data. METHODS: Patients were randomized to receive two cycles of neoadjuvant methotrexate, doxorubicin, vinblastine, and cisplatin followed by radical cystectomy or radical cystectomy alone. Health-related quality of life was measured using the Functional Assessment of Cancer Therapy-Bladder (version 4) questionnaire before the protocol treatments, after neoadjuvant chemotherapy, after radical cystectomy and 1 year after registration. RESULTS: A total of 99 patients were analysed. No statistically significant differences in postoperative health-related quality of life were found between the arms. In the neoadjuvant chemotherapy arm, the scores after neoadjuvant chemotherapy were significantly lower than the baseline scores in physical well-being, functional well-being, Functional Assessment of Cancer Therapy-General total, weight loss, diarrhoea, appetite, body appearance, embarrassment by ostomy appliance and total Functional Assessment of Cancer Therapy-Bladder. However, there was no difference in scores for these domains, except for embarrassment by ostomy appliance, between the two arms after radical cystectomy and 1 year after registration. CONCLUSIONS: Although health-related quality of life declined during neoadjuvant chemotherapy, no negative effect of neoadjuvant chemotherapy on health-related quality of life was apparent after radical cystectomy. These data support the view that neoadjuvant chemotherapy can be considered as a standard of care for patients with muscle-invasive bladder cancer regarding health-related quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Neoplasias de la Vejiga Urinaria / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias de los Músculos Tipo de estudio: Clinical_trials / Guideline Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Jpn J Clin Oncol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Neoplasias de la Vejiga Urinaria / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias de los Músculos Tipo de estudio: Clinical_trials / Guideline Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Jpn J Clin Oncol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido