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Self-compassion and dorsolateral prefrontal cortex activity during sad self-face recognition in depressed adolescents.
Liu, Guanmin; Zhang, Na; Teoh, Jia Yuan; Egan, Christine; Zeffiro, Thomas A; Davidson, Richard J; Quevedo, Karina.
Afiliación
  • Liu G; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI53703, USA.
  • Zhang N; Department of Psychiatry, University of Minnesota, Minneapolis, MN55454, USA.
  • Teoh JY; Department of Human Development and Family Sciences, University of Connecticut, Stamford, CT06901, USA.
  • Egan C; Department of Psychiatry, University of Minnesota, Minneapolis, MN55454, USA.
  • Zeffiro TA; Department of Neuroscience, University of Minnesota, Minneapolis, MN55455, USA.
  • Davidson RJ; University of Maryland School of Medicine, Baltimore, MD21201, USA.
  • Quevedo K; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI53703, USA.
Psychol Med ; 52(5): 864-873, 2022 04.
Article en En | MEDLINE | ID: mdl-32698918
BACKGROUND: Given the prevalence of adolescent depression and the modest effects of current treatments, research ought to inform development of effective intervention strategies. Self-compassion is inversely associated with depression, and self-compassion interventions have demonstrated promising effects on reducing depression. However, little is known about the neural mechanisms underlying that relationship. Maladaptive self-processing is a characteristic of depression that contributes to the onset and chronicity of depression. Because our own face is an automatic and direct cue for self-processing, this study investigated whether self-compassion was associated with neural responses during sad v. neutral self-face recognition and explore their relationship with depression severity in depressed adolescents and healthy controls (HCs). METHODS: During functional magnetic resonance imaging, 81 depressed youth and 37 HCs were instructed to identify whether morphed self or other faces with sad, happy, or neutral expressions resembled their own. RESULTS: Self-compassion correlated negatively with activity during sad v. neutral self-face recognition in the dorsal anterior cingulate cortex in the total sample, and in the right posterior cingulate cortex/precuneus in HCs, respectively. In depressed adolescents, higher self-compassion correlated with lower activity during sad v. neutral self-face recognition in the right dorsolateral prefrontal cortex (DLPFC), implying that less cognitive effort might be needed to avoid dwelling on sad self-faces and/or regulate negative affect induced by them. Moreover, higher self-compassion mediated the relationship between lower DLPFC activity and reduced depression severity. CONCLUSIONS: Our findings imply that DLPFC activity might be a biological marker of a successful self-compassion intervention as potential treatment for adolescent depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reconocimiento Facial Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Humans Idioma: En Revista: Psychol Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reconocimiento Facial Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Humans Idioma: En Revista: Psychol Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido