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Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth.
Schiffmann, L M; Werthenbach, J P; Heintges-Kleinhofer, F; Seeger, J M; Fritsch, M; Günther, S D; Willenborg, S; Brodesser, S; Lucas, C; Jüngst, C; Albert, M C; Schorn, F; Witt, A; Moraes, C T; Bruns, C J; Pasparakis, M; Krönke, M; Eming, S A; Coutelle, O; Kashkar, H.
Afiliación
  • Schiffmann LM; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Werthenbach JP; Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Heintges-Kleinhofer F; Centre for Integrated Oncology (CIO) Cologne Bonn, Cologne, Germany.
  • Seeger JM; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Fritsch M; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Günther SD; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Willenborg S; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Brodesser S; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Lucas C; Centre for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Jüngst C; Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Albert MC; Lipidomics/Metabolomics Facility, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Schorn F; Lipidomics/Metabolomics Facility, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Witt A; Imaging Facility, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Moraes CT; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Bruns CJ; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Pasparakis M; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Krönke M; Department of Neurology, Miller School of Medicine Miami, University of Miami, Miami, Florida, USA.
  • Eming SA; Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Coutelle O; Centre for Integrated Oncology (CIO) Cologne Bonn, Cologne, Germany.
  • Kashkar H; Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Nat Commun ; 11(1): 3653, 2020 07 21.
Article en En | MEDLINE | ID: mdl-32694534
The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here we assess the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase (COX) specifically in mouse ECs, providing a model for vasculature-restricted respiratory deficiency. We show that EC-specific cox10 ablation results in deficient vascular development causing embryonic lethality. In adult mice induction of EC-specific cox10 gene deletion produces no overt phenotype. However, the angiogenic capacity of COX-deficient ECs is severely compromised under energetically demanding conditions, as revealed by significantly delayed wound-healing and impaired tumour growth. We provide genetic evidence for a requirement of mitochondrial respiration in vascular endothelial cells for neoangiogenesis during development, tissue repair and cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Neovascularización Fisiológica / Mitocondrias / Neoplasias / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Neovascularización Fisiológica / Mitocondrias / Neoplasias / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido