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Cardioprotective effects of pharmacological blockade of the mitochondrial calcium uniporter on myocardial ischemia-reperfusion injury.
Menezes-Rodrigues, Francisco Sandro; Tavares, José Gustavo Padrão; Vasques, Enio Rodrigues; Errante, Paolo Ruggero; Araújo, Erisvaldo Amarante de; Pires-Oliveira, Marcelo; Scorza, Carla Alessandra; Scorza, Fúlvio Alexandre; Taha, Murched Omar; Caricati-Neto, Afonso.
Afiliación
  • Menezes-Rodrigues FS; Fellow PhD degree, Postgraduate Program in Pharmacology, Universidade Federal de São Paulo (UNIFESP), Brazil. Conception and design of the study, analysis and interpretation of data, manuscript writing.
  • Tavares JGP; Fellow PhD degree, Postgraduate Program in Pharmacology, Universidade Federal de São Paulo (UNIFESP), Brazil. Conception and design of the study, analysis and interpretation of data, manuscript writing.
  • Vasques ER; Fellow PhD degree, Laboratory of Liver Surgery and Transplant (LIM/37), School of Medicine, Universidade de São Paulo (USP), Brazil. Analysis and interpretation of data.
  • Errante PR; Fellow PhD degree, Postgraduate Program in Pharmacology, UNIFESP, Sao Paulo-SP, Brazil. Analysis and interpretation of data, manuscript writing.
  • Araújo EA; Fellow MSc degree, Postgraduate Program in Pharmacology, UNIFESP, Sao Paulo-SP, Brazil. Analysis and interpretation of data.
  • Pires-Oliveira M; PhD, Assistant Professor, School of Medicine, União Metropolitana de Educação e Cultura (UNIME), Lauro de Freitas-BA, Brazil. Manuscript preparation and writing.
  • Scorza CA; PhD, Associate Professor, Department of Neurology and Neurosurgery, UNIFESP, Sao Paulo-SP, Brazil. Critical revision.
  • Scorza FA; PhD, Associate Professor, Department of Neurology and Neurosurgery, UNIFESP, Sao Paulo-SP, Brazil. Critical revision.
  • Taha MO; PhD, Associate Professor, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Technical procedures, interpretation of data.
  • Caricati-Neto A; PhD, Associate Professor, Department of Pharmacology, UNIFESP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.
Acta Cir Bras ; 35(3): e202000306, 2020 May 20.
Article en En | MEDLINE | ID: mdl-32692797
PURPOSE: To evaluate whether the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of mitochondrial Ca2+ uniporter (MCU) protects the myocardium against injuries caused by cardiac ischemia and reperfusion (CIR). METHODS: CIR was induced in adult male Wistar rats (300-350 g) by occlusion of the left anterior descendent coronary artery (10 min), followed by reperfusion (120 min). Rats were treated with different doses of MCU blocker ruthenium red (RuR), administered 5 min before ischemia or reperfusion. RESULTS: In untreated rats, the incidences of ventricular arrhythmias (VA), atrioventricular block (AVB) and the lethality (LET) induced by CIR were 85%, 79% and 70%, respectively. In rats treated with RuR before ischemia, the incidences of VA, AVB and LET were significantly reduced to 62%, 25% and 25%, respectively. In rats treated with RuR after ischemia, the incidences of VA, AVB and LET were significantly reduced to 50%, 25% and 25%, respectively. CONCLUSION: The significant reduction of the incidence of CIR-induced VA, AVB and LET produced by the treatment with RuR indicates that the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of MCU can protect the myocardium against injuries caused by CIR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales de Calcio / Daño por Reperfusión Miocárdica / Isquemia Miocárdica Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2020 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales de Calcio / Daño por Reperfusión Miocárdica / Isquemia Miocárdica Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2020 Tipo del documento: Article Pais de publicación: Brasil