Early-life stress affects behavioral and neurochemical parameters differently in male and female juvenile Wistar rats.
Int J Dev Neurosci
; 80(6): 547-557, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-32683715
Neonatal handling is an early life stressor that leads to behavioral and neurochemical changes in adult rats in a sex-specific manner and possibly affects earlier stages of development. Here, we investigated the effects of neonatal handling (days 1-10 after birth) on juvenile rats focusing on biochemical parameters and olfactory memory after weaning. Male neonatal handled rats performed more crossings on the hole-board task, increased Na+ /K+ -ATPase activity in the olfactory bulb, and decreased acetylcholinesterase activity in the hippocampus versus non-handled males. Female neonatal handled animals increased the number of rearing and nose-pokes on the hole-board task, decreased glutathione peroxidase activity, and total thiol content in the hippocampus versus non-handled females. This study reinforces that early life stress affects behavioral and neurochemical parameters in a sex-specific manner even before the puberty onset.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acetilcolinesterasa
/
Estrés Psicológico
/
Conducta Animal
/
Manejo Psicológico
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Hipocampo
/
Actividad Motora
Límite:
Animals
Idioma:
En
Revista:
Int J Dev Neurosci
Año:
2020
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Estados Unidos