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Longitudinal determination of resilience in humans to identify mechanisms of resilience to modern-life stressors: the longitudinal resilience assessment (LORA) study.
Chmitorz, A; Neumann, R J; Kollmann, B; Ahrens, K F; Öhlschläger, S; Goldbach, N; Weichert, D; Schick, A; Lutz, B; Plichta, M M; Fiebach, C J; Wessa, M; Kalisch, R; Tüscher, O; Lieb, K; Reif, A.
Afiliación
  • Chmitorz A; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
  • Neumann RJ; Faculty of Social Work, Health Care and Nursing Science, Esslingen University of Applied Sciences, Esslingen am Neckar, Germany.
  • Kollmann B; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
  • Ahrens KF; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany. bianca.kollmann@lir-mainz.de.
  • Öhlschläger S; Leibniz Institute for Resilience Research (LIR), Wallstraße 7, Mainz, 55122, Deutschland. bianca.kollmann@lir-mainz.de.
  • Goldbach N; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
  • Weichert D; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
  • Schick A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
  • Lutz B; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
  • Plichta MM; Leibniz Institute for Resilience Research (LIR), Wallstraße 7, Mainz, 55122, Deutschland.
  • Fiebach CJ; Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), University Medical Center Mainz, Mainz, Germany.
  • Wessa M; Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Kalisch R; Leibniz Institute for Resilience Research (LIR), Wallstraße 7, Mainz, 55122, Deutschland.
  • Tüscher O; Department of Physiological Chemistry, University Medical Center Mainz, Mainz, Germany.
  • Lieb K; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
  • Reif A; Department of Psychology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Eur Arch Psychiatry Clin Neurosci ; 271(6): 1035-1051, 2021 Sep.
Article en En | MEDLINE | ID: mdl-32683526
Resilience is the maintenance and/or quick recovery of mental health during and after periods of adversity. It is conceptualized to result from a dynamic process of successful adaptation to stressors. Up to now, a large number of resilience factors have been proposed, but the mechanisms underlying resilience are not yet understood. To shed light on the complex and time-varying processes of resilience that lead to a positive long-term outcome in the face of adversity, the Longitudinal Resilience Assessment (LORA) study has been established. In this study, 1191 healthy participants are followed up at 3- and 18-month intervals over a course of 4.5 years at two study centers in Germany. Baseline and 18-month visits entail multimodal phenotyping, including the assessment of mental health status, sociodemographic and lifestyle variables, resilience factors, life history, neuropsychological assessments (of proposed resilience mechanisms), and biomaterials (blood for genetic and epigenetic, stool for microbiome, and hair for cortisol analysis). At 3-monthly online assessments, subjects are monitored for subsequent exposure to stressors as well as mental health measures, which allows for a quantitative assessment of stressor-dependent changes in mental health as the main outcome. Descriptive analyses of mental health, number of stressors including major life events, daily hassles, perceived stress, and the ability to recover from stress are here presented for the baseline sample. The LORA study is unique in its design and will pave the way for a better understanding of resilience mechanisms in humans and for further development of interventions to successfully prevent stress-related disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Resiliencia Psicológica Tipo de estudio: Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Resiliencia Psicológica Tipo de estudio: Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania