Your browser doesn't support javascript.
loading
Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.
Dunbar, Ellyn; Greer, Phil J; Melhem, Nadine; Alkaade, Samer; Amann, Stephen T; Brand, Randall; Coté, Gregory A; Forsmark, Christopher E; Gardner, Timothy B; Gelrud, Andres; Guda, Nalini M; LaRusch, Jessica; Lewis, Michele D; Machicado, Jorge D; Muniraj, Thiruvengadam; Papachristou, Georgios I; Romagnuolo, Joseph; Sandhu, Bimaljit S; Sherman, Stuart; Wilcox, Charles M; Singh, Vikesh K; Yadav, Dhiraj; Whitcomb, David C.
Afiliación
  • Dunbar E; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Greer PJ; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • Melhem N; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Alkaade S; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Amann ST; Department of Medicine, St. Louis University, St. Louis, MO, USA.
  • Brand R; Mercy Clinic Gastroenterology, St. Louis, MO, USA.
  • Coté GA; North Mississippi Medical Center, Tupelo, MS, USA.
  • Forsmark CE; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Gardner TB; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Gelrud A; Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Guda NM; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
  • LaRusch J; Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Lewis MD; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Machicado JD; Department of Medicine, University of Cincinnati, Cincinnati, OH, USA.
  • Muniraj T; GastroHealth, Miami, FL, USA.
  • Papachristou GI; GI Associates, Milwaukee, WI, USA.
  • Romagnuolo J; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Sandhu BS; Ariel Precision Medicine, Pittsburgh, PA, USA.
  • Sherman S; Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
  • Wilcox CM; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Singh VK; Division of Gastroenterology and Hepatology, Mayo Clinic Health System, Eau Claire, WI, USA.
  • Yadav D; Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.
  • Whitcomb DC; Department of Medicine, Yale University Medical Center, New Haven, CT, USA.
J Gastroenterol ; 55(10): 1000-1009, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32681239
BACKGROUND: Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain experience in RAP/CP patients. STUDY: A retrospective study was done using North American Pancreatitis Study II (NAPS2) genotyped RAP and CP patients with completed case report forms (n = 1,357). Subjects were divided based on pattern of pain and pain severity as constant-severe pain (n = 787) versus not constant-severe pain (n = 570) to conduct a nested genome-wide association study. The association between reported antidepressant medication use and depression gene loci was tested. RESULTS: Constant-severe pain was reported in 58% (n = 787) of pancreatitis patients. No differences in sex or alcohol consumption were found based on pain severity. Antidepressant use was reported in 28% (n = 223), and they had lower SF-12 mental quality of life (MCS, p < 2.2 × 10- 16). Fifteen loci associated with constant-severe pain (p < 0.00001) were found to be in or near depression-associated genes including ROBO2, CTNND2, SGCZ, CNTN5 and BAIAP2. Three of these genes respond to antidepressant use (SGCZ, ROBO2, and CTNND2). CONCLUSION: Depression is a major co-factor in the pain experience. This genetic predisposition to depression may have utility in counseling patients and in instituting early antidepressant therapy for pain management of pancreatitis patients. Prospective randomized trials are warranted. CLINICAL TRIALS REGISTRATION: Clinicaltriasl.gov.# NCT01545167.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Trastorno Depresivo Mayor / Pancreatitis Crónica / Antidepresivos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Trastorno Depresivo Mayor / Pancreatitis Crónica / Antidepresivos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Japón