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A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics.
Choi, Seung-Min; Jeong, Jae-Chan; Kim, Jinsun; Lim, Eul-Gyoon; Kim, Chang-Beom; Park, Sang-Jin; Song, Dae-Yong; Krause, Hans-Joachim; Hong, Hyobong; Kweon, In So.
Afiliación
  • Choi SM; Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea. ccsmm@etri.re.kr.
  • Jeong JC; Division of Future Vehicle, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. ccsmm@etri.re.kr.
  • Kim J; Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea.
  • Lim EG; Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea.
  • Kim CB; Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea.
  • Park SJ; Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea.
  • Song DY; Department of Anatomy and Neuroscience, School of Medicine, Eulji University, Daejeon, Republic of Korea.
  • Krause HJ; Department of Anatomy and Neuroscience, School of Medicine, Eulji University, Daejeon, Republic of Korea.
  • Hong H; Institute of Biological Information Processing, Bioelectronics (IBI-3), Forschungszentrum Jülich, Jülich, Germany.
  • Kweon IS; Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea.
Sci Rep ; 10(1): 11833, 2020 07 16.
Article en En | MEDLINE | ID: mdl-32678265
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is [Formula: see text] in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is [Formula: see text], 10 mg/mL, [Formula: see text] (Fe).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Encéfalo / Imagenología Tridimensional / Pruebas en el Punto de Atención / Nanopartículas Magnéticas de Óxido de Hierro Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Encéfalo / Imagenología Tridimensional / Pruebas en el Punto de Atención / Nanopartículas Magnéticas de Óxido de Hierro Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido