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Characterising phospholipids and free fatty acids in patients with schizophrenia: A case-control study.
Wang, Dongfang; Sun, Xiaoyu; Maziade, Michel; Mao, Wei; Zhang, Chuanbo; Wang, Jingyu; Cao, Bing.
Afiliación
  • Wang D; Institute of Blood Transfusion, Chongqing Blood Center, Chongqing, P. R. China.
  • Sun X; Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, P. R. China.
  • Maziade M; Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, P. R. China.
  • Mao W; Centre de recherche CERVO, Centre Intégré Universitaire de Santé et des Services Sociaux de la Capitale-Nationale, Québec, Canada.
  • Zhang C; Département de Psychiatrie et Neurosciences, Faculté de Médecine, Université Laval, Québec, Canada.
  • Wang J; Institute of Blood Transfusion, Chongqing Blood Center, Chongqing, P. R. China.
  • Cao B; Psychiatric Department, Weifang Mental Health Center, Weifang, P. R. China.
World J Biol Psychiatry ; 22(3): 161-174, 2021 03.
Article en En | MEDLINE | ID: mdl-32677491
OBJECTIVES: Previous studies have indicated that schizophrenia (SCZ) is linked to abnormal phospholipid and fatty acid metabolism. However, comprehensive analysis of phospholipids and free fatty acids (FFAs) for SCZ is very limited. Herein, we sought to compare serum levels of phospholipids and FFAs between patients with SCZ and healthy controls (HCs). METHODS: One hundred and nineteen SCZ patients and 109 HCs were enrolled in the study. The levels of 177 phospholipids and FFAs were measured in serum samples using a targeted liquid chromatography-mass spectrometry (LC-MS)-based platform. RESULTS: One hundred and ten metabolites, including 16 FFAs, 25 phosphatidylcholines, 23 lysophosphatidylcholines, 11 phosphatidylcholine plasmalogens, 7 phosphatidylethanolamines, 9 lysophosphatidylethanolamines, 6 phosphatidylethanolamine plasmalogens, and 13 sphingomyelins, were observed to be significantly altered in SCZ patients compared to HCs. These disturbances may represent underlying pathophysiology, including but not limited to altered activity of phospholipases and acyltransferases, increased oxidative stress, dysfunctional oligodendrocyte glycosynapses, and elevated lipid mobilisation and ß-oxidation. CONCLUSIONS: Our findings suggest that complex lipid profile abnormalities are associated with SCZ. This study may contribute to investigating the role of phospholipid and FFA alterations in the pathoetiology of SCZ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Ácidos Grasos no Esterificados Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: World J Biol Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Ácidos Grasos no Esterificados Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: World J Biol Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido