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Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979.
Pramisandi, Amila; Dobashi, Kazuyuki; Mori, Mihoko; Nonaka, Kenichi; Matsumoto, Atsuko; Tokiwa, Toshiyuki; Higo, Mayuka; Amalia, Eri; Nurkanto, Arif; Inaoka, Daniel Ken; Waluyo, Danang; Kita, Kiyoshi; Nozaki, Tomoyoshi; Omura, Satoshi; Shiomi, Kazuro.
Afiliación
  • Pramisandi A; Graduate School of Infection Control Sciences, Kitasato University.
  • Dobashi K; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Mori M; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Nonaka K; Graduate School of Infection Control Sciences, Kitasato University.
  • Matsumoto A; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Tokiwa T; Graduate School of Infection Control Sciences, Kitasato University.
  • Higo M; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Kristiningrum; Graduate School of Infection Control Sciences, Kitasato University.
  • Amalia E; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Nurkanto A; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Inaoka DK; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Waluyo D; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Kita K; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • Omura S; Research Center for Biology, Indonesia Institute of Sciences (LIPI).
  • Shiomi K; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
J Gen Appl Microbiol ; 66(5): 273-278, 2020 Nov 30.
Article en En | MEDLINE | ID: mdl-32669511
An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. We obtained altenusin (1), which inhibits PfDHODH, with an IC50 value of 5.9 µM, along with other metabolites: mitorubrinol (2) and mitorubrinic acid (3). Compounds 1 and 2 inhibited PfDHODH but displayed no activity against the human orthologue. They also inhibited P. falciparum 3D7 cell growth in vitro. Compound 3 showed little PfDHODH inhibitory activity or cell growth inhibitory activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Proteínas Protozoarias / Talaromyces / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Antimaláricos Límite: Humans Idioma: En Revista: J Gen Appl Microbiol Año: 2020 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Proteínas Protozoarias / Talaromyces / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Antimaláricos Límite: Humans Idioma: En Revista: J Gen Appl Microbiol Año: 2020 Tipo del documento: Article Pais de publicación: Japón