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Childhood Urinary Tract Infections and Pregnancy-Related Complications in Adult Women.
Honkila, Minna; Hannula, Annukka; Pokka, Tytti; Hanni, Anna-Maija; Salo, Jarmo; Renko, Marjo; Vääräsmäki, Marja; Perhomaa, Marja; Keskimäinen, Elina; Uhari, Matti; Tapiainen, Terhi.
Afiliación
  • Honkila M; Departments of Pediatrics and Adolescent Medicine, minna.honkila@oulu.fi.
  • Hannula A; PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
  • Pokka T; PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
  • Hanni AM; Departments of Pediatrics and Adolescent Medicine.
  • Salo J; PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
  • Renko M; Health Care Centre, Oulu, Finland.
  • Vääräsmäki M; Departments of Pediatrics and Adolescent Medicine.
  • Perhomaa M; PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
  • Keskimäinen E; PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
  • Uhari M; Department of Pediatrics, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; and.
  • Tapiainen T; PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
Pediatrics ; 146(2)2020 08.
Article en En | MEDLINE | ID: mdl-32669403
BACKGROUND AND OBJECTIVES: Long-term outcomes of urinary tract infection (UTI) in childhood are not well known. Pregnancy may reveal latent renal damage caused by a UTI because of stress on the kidneys. METHODS: Our cohort included adult women with an ultrasonography taken because of a childhood UTI in 1981-1991 (N = 1175). Nine women with a severe congenital kidney malformation or urinary tract obstruction were excluded. Altogether, 260 mothers with a childhood UTI and 500 population-based control mothers without a childhood UTI matched for age, and delivery dates were compared. Our primary end point was the proportion of women with essential or gestational hypertension, preeclampsia, proteinuria, or pyelonephritis during the first pregnancy. RESULTS: The pregnancy outcomes of the women with a UTI in childhood did not differ from those of the controls because 105 of 260 (40%) patients met the primary end point compared with 204 of 500 (41%) controls (relative risk [RR] 0.99; 95% confidence interval [CI] 0.82 to 1.2; P = .91). Similarly, there were no significant differences between the 2 groups in essential hypertension (RR 1.0; 95% CI 0.65 to 1.6; P = .92), gestational hypertension (RR 0.93; 95% CI 0.74 to 1.2; P = .54), preeclampsia (RR 1.5; 95% CI 0.91 to 2.5; P = .11), proteinuria (RR 1.2; 95% CI 0.81 to 1.8; P = .36) or pyelonephritis (2 controls and none of the patients; P = .55) during the first pregnancy. CONCLUSIONS: Childhood UTIs did not increase the risk of pregnancy-related complications in this controlled population-based study. Thus, UTIs in childhood without severe urinary tract abnormalities appear to have a minimal effect on kidney health in early adulthood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Child / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Pediatrics Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Child / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Pediatrics Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos