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PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN.
Pastore, Friederike; Bhagwat, Neha; Pastore, Alessandro; Radzisheuskaya, Aliaksandra; Karzai, Abdul; Krishnan, Aishwarya; Li, Bing; Bowman, Robert L; Xiao, Wenbin; Viny, Aaron D; Zouak, Anouar; Park, Young C; Cordner, Keith B; Braunstein, Stephanie; Maag, Jesper L; Grego, Alexander; Mehta, Jaanvi; Wang, Min; Lin, Hong; Durham, Benjamin H; Koche, Richard P; Rampal, Raajit K; Helin, Kristian; Scherle, Peggy; Vaddi, Kris; Levine, Ross L.
Afiliación
  • Pastore F; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Bhagwat N; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Pastore A; Prelude Therapeutics Inc., Wilmington, Delaware.
  • Radzisheuskaya A; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Karzai A; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Krishnan A; Cell Biology Program, Memorial Sloan Kettering CancerCenter, New York, New York.
  • Li B; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Bowman RL; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Xiao W; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Viny AD; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Zouak A; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Park YC; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Cordner KB; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Braunstein S; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Maag JL; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Grego A; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Mehta J; Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Wang M; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Lin H; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Durham BH; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Rampal RK; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Helin K; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Scherle P; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Vaddi K; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Levine RL; Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Cancer Discov ; 10(11): 1742-1757, 2020 11.
Article en En | MEDLINE | ID: mdl-32669286
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Factor de Transcripción E2F1 / Janus Quinasa 2 / Redes Reguladoras de Genes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Discov Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Factor de Transcripción E2F1 / Janus Quinasa 2 / Redes Reguladoras de Genes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Discov Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos