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High levels of boron promote anchorage-independent growth of nontumorigenic cells.
Xu, Huadong; Hashimoto, Kazunori; Maeda, Masao; Azimi, Mohammad Daud; Fayaz, Said Hafizullah; Chen, Wei; Hamajima, Nobuyuki; Kato, Masashi.
Afiliación
  • Xu H; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan.
  • Hashimoto K; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan.
  • Maeda M; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
  • Azimi MD; Human Resources of Ministry of Public Health, Kabul, Afghanistan.
  • Fayaz SH; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Administrative Office of the President, Deputy Public Relations and Outreach, Kabul, Afghanistan.
  • Chen W; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan.
  • Hamajima N; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
  • Kato M; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan; Department of Biomedical Sciences, College of Life and Health Sc
Environ Pollut ; 266(Pt 3): 115094, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32659568
WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 µM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 µM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Boro / Fosfatidilinositol 3-Quinasas Límite: Humans Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Boro / Fosfatidilinositol 3-Quinasas Límite: Humans Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido