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Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study.
Ferruccio, Naika P; Tosato, Sarah; Lappin, Julia M; Heslin, Margaret; Donoghue, Kim; Giordano, Annalisa; Lomas, Ben; Reininghaus, Ulrich; Onyejiaka, Adanna; Chan, Raymond C K; Croudace, Tim; Jones, Peter B; Murray, Robin M; Fearon, Paul; Doody, Gillian A; Morgan, Craig; Dazzan, Paola.
Afiliación
  • Ferruccio NP; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Tosato S; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Lappin JM; Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
  • Heslin M; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
  • Donoghue K; Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Giordano A; Department of Addictions, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Lomas B; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Reininghaus U; Department of Psychiatry, University of Nottingham, Nottingham, UK.
  • Onyejiaka A; Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Chan RCK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Croudace T; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
  • Jones PB; School of Health Sciences, University of Dundee, Dundee, UK.
  • Murray RM; University of Cambridge, and Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
  • Fearon P; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Doody GA; Discipline of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
  • Morgan C; Department of Psychiatry, University of Nottingham, Nottingham, UK.
  • Dazzan P; Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Schizophr Bull ; 47(1): 118-127, 2021 01 23.
Article en En | MEDLINE | ID: mdl-32656567
Minor neurological signs are subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts present in excess in the early stages of psychosis. Still, it remains unclear whether at least some of these signs represent trait or state markers for psychosis and whether they are markers of long-term disease outcome of clinical utility. We examined the relationship between neurological function at illness onset assessed with the Neurological Evaluation Scale and subsequent illness course in 233 patients from AESOP-10 (Aetiology and Ethnicity in Schizophrenia and Other Psychoses), a 10-year follow-up study of a population-based cohort of individuals recruited at the time of their first episode of psychosis in the United Kingdom. In 56 of these patients, we also explored changes in neurological function over time. We included a group of 172 individuals without psychosis as controls. After 10 years, 147 (63%) patients had developed a non-remitting course of illness, and 86 (37%) a remitting course. Already at first presentation, patients who developed a non-remitting course had significantly more primary, motor coordination, and total signs than both remitting patients and healthy controls. While Motor Coordination signs did not change over time, rates of Primary, Sensory Integration, and Total signs increased, independently of illness course type. These findings suggest that motor coordination problems could be a useful early, quick, and easily detectable marker of subsequent clinical outcome. With other motor abnormalities, a measure of motor incoordination could contribute to the identification of the most vulnerable individuals, who could benefit from targeted and more assertive treatment approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Percepción / Desempeño Psicomotor / Trastornos Psicóticos / Esquizofrenia / Progresión de la Enfermedad / Discinesias / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Schizophr Bull Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Percepción / Desempeño Psicomotor / Trastornos Psicóticos / Esquizofrenia / Progresión de la Enfermedad / Discinesias / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Schizophr Bull Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos