Silver complexes with heterocyclic thioamide and tertiary arylphosphane ligands: Synthesis, crystal structures, in vitro and in silico antibacterial and cytotoxic activity, and interaction with DNA.

Anastasiadou, Despoina; Geromichalou, Elena; Tsavea, Eleni; Psomas, George; Hatzidimitriou, Antonios G; Kalogiannis, Stavros; Geromichalos, George; Trafalis, Dimitrios; Dalezis, Panagiotis; Aslanidis, Paraskevas

Anastasiadou, Despoina; Geromichalou, Elena; Tsavea, Eleni; Psomas, George; Hatzidimitriou, Antonios G; Kalogiannis, Stavros; Geromichalos, George; Trafalis, Dimitrios; Dalezis, Panagiotis; Aslanidis, Paraskevas.

Afiliación

Anastasiadou D; Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Geromichalou E; Laboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens 11527, Greece.
Tsavea E; Department of Nutritional Sciences and Dietetics, International Hellenic University, Sindos, Thessaloniki, Greece.
Psomas G; Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address: gepsomas@chem.auth.gr.
Hatzidimitriou AG; Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Kalogiannis S; Department of Nutritional Sciences and Dietetics, International Hellenic University, Sindos, Thessaloniki, Greece.
Geromichalos G; Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Trafalis D; Laboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens 11527, Greece. Electronic address: dtrafal@med.uoa.gr.
Dalezis P; Laboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens 11527, Greece.
Aslanidis P; Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address: aslanidi@chem.auth.gr.

J Inorg Biochem ; 210: 111167, 2020 09.

Article en En | MEDLINE | ID: mdl-32653633

Asunto(s)

Antibacterianos/farmacología; Antineoplásicos/farmacología; Complejos de Coordinación/farmacología; Sustancias Intercalantes/farmacología; Compuestos Organofosforados/farmacología; Tioamidas/farmacología; Animales; Antibacterianos/síntesis química; Antibacterianos/metabolismo; Antineoplásicos/síntesis química; Antineoplásicos/metabolismo; Bacterias/efectos de los fármacos; Bovinos; Complejos de Coordinación/síntesis química; Complejos de Coordinación/metabolismo; Quinasa 6 Dependiente de la Ciclina/metabolismo; ADN/metabolismo; Girasa de ADN/metabolismo; Proteínas de Escherichia coli/metabolismo; Receptor alfa de Estrógeno/metabolismo; Humanos; Sustancias Intercalantes/síntesis química; Sustancias Intercalantes/metabolismo; Ligandos; Pruebas de Sensibilidad Microbiana; Simulación del Acoplamiento Molecular; Compuestos Organofosforados/síntesis química; Compuestos Organofosforados/metabolismo; Unión Proteica; Plata/química; Tioamidas/síntesis química; Tioamidas/metabolismo

Palabras clave

Antibacterial activity; Cytotoxic and cytostatic activity; Interaction with DNA; Silver complexes; in silico molecular docking

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Tioamidas / Complejos de Coordinación / Sustancias Intercalantes / Antibacterianos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Inorg Biochem Año: 2020 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos

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