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Low Fraction Size Re-irradiation for Large Volume Recurrence of Glial Tumours.
Dobi, Ágnes; Darázs, Barbara; Fodor, Emese; Cserháti, Adrienne; Együd, Zsófia; Maráz, Anikó; László, Szilvia; Dodd, Leopold; Reisz, Zita; Barzó, Pál; Oláh, Judit; Hideghéty, Katalin.
Afiliación
  • Dobi Á; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary. dobiagnes@gmail.com.
  • Darázs B; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Fodor E; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Cserháti A; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Együd Z; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Maráz A; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • László S; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Dodd L; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Reisz Z; Department of Pathology, University of Szeged, Állomás utca 1, Szeged, H-6725, Hungary.
  • Barzó P; Department of Neurosurgery, University of Szeged, Semmelweis utca 6, Szeged, H-6725, Hungary.
  • Oláh J; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
  • Hideghéty K; Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary.
Pathol Oncol Res ; 26(4): 2651-2658, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32648211
The aim of the present study was to evaluate the efficacy of re-irradiation (re-RT) in patients with advanced local relapses of glial tumours and to define the factors influencing the result of the hyper-fractionated external beam therapy on progression after primary management. We have analysed the data of 55 patients with brain tumours (GBM: 28) on progression, who were re-irradiated between January 2007 and December 2018. The mean volume of the recurrent tumour was 118 cm3, and the mean planning target volume (PTV) was 316 cm3, to which 32 Gy was delivered in 20 fractions at least 7.7 months after the first radiotherapy, using 3D conformal radiotherapy (CRT) or intensity modulated radiotherapy (IMRT). The median overall survival (mOS) from the re-RT was 8.4 months, and the 6-month and the 12-month OS rate was 64% and 31%, respectively. The most important factors by univariate analysis, which significantly improved the outcome of re-RT were the longer time interval between the diagnosis and second radiotherapy (p = 0.029), the lower histology grade (p = 0.034), volume of the recurrent tumour (p = 0.006) and Karnofsky performance status (KPS) (p = 0.009) at the re-irradiation. Our low fraction size re-irradiation ≥ 8 months after the first radiotherapy proved to be safe and beneficial for patients with large volume recurrent glial tumours.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Radioterapia Conformacional / Reirradiación / Glioma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Oncol Res Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Radioterapia Conformacional / Reirradiación / Glioma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Oncol Res Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza