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DNA methylation biomarkers of future health outcomes in children.
Shanthikumar, Shivanthan; Neeland, Melanie R; Maksimovic, Jovana; Ranganathan, Sarath C; Saffery, Richard.
Afiliación
  • Shanthikumar S; Respiratory and Sleep Medicine, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria, 3052, Australia. shivanthan.shanthikumar@rch.org.au.
  • Neeland MR; Respiratory Diseases, Murdoch Children's Research Institute, Melbourne, Australia. shivanthan.shanthikumar@rch.org.au.
  • Maksimovic J; Department of Paediatrics, The University of Melbourne, Melbourne, Australia. shivanthan.shanthikumar@rch.org.au.
  • Ranganathan SC; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
  • Saffery R; Epigenetics, Murdoch Children's Research Institute, Melbourne, Australia.
Mol Cell Pediatr ; 7(1): 7, 2020 Jul 09.
Article en En | MEDLINE | ID: mdl-32642955
Biomarkers which predict future health outcomes are key to the goals of precision health. Such biomarkers do not have to be involved in the causal pathway of a disease, and their performance is best assessed using statistical tests of clinical performance and evaluation of net health impact. DNA methylation is the most commonly studied epigenetic process and represents a potential biomarker of future health outcomes. We review 25 studies in non-oncological paediatric conditions where DNA methylation biomarkers of future health outcomes are assessed. Whilst a number of positive findings have been described, the body of evidence is severely limited by issues with outcome measures, tissue-specific samples, accounting for sample cell type heterogeneity, lack of appropriate statistical testing, small effect sizes, limited validation, and no assessment of net health impact. Future studies should concentrate on careful study design to overcome these issues, and integration of DNA methylation data with other 'omic', clinical, and environmental data to generate the most clinically useful biomarkers of paediatric disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Pediatr Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Pediatr Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania